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OBJECTIVE To evaluate the safety, tolerability, and pharmacokinetics (PK) of BIIB033 (anti-LINGO-1 monoclonal antibody) in healthy volunteers and participants with multiple sclerosis (MS). METHODS In 2 separate randomized, placebo-controlled studies, single ascending doses (SAD; 0.1-100 mg/kg) of BIIB033 or placebo were administered via IV infusion or(More)
DC/DC switched power converter is one of main control power source in DC driving systems. It determines the performances of DC driving systems, such as speedup calmness and fast response. This paper designed the controller based on the adaptive backstepping sliding mode control principle to drive a class of buck DC/DC switched power converters to operate.(More)
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