Jim Yorke

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Since the publication of the human genome in 2001, the price and the time of DNA sequencing have dropped dramatically. The genome of many more species have since been sequenced, and genome sequencing is an ever more important tool for biologists. This trend will likely revolutionize biology and medicine in the near future where the genome sequence of each(More)
Over the 50 year history of Numerical Weather Prediction (NWP), the focus has been on the modeling and prediction of meteorological parameters such as surface pressure, temperature, wind, and precipitation. However, due to concerns over pollution and to recent advancements in satellite technologies, an increasing number of NWP systems have been upgraded to(More)
We investigate the evolution of three different types of discrete dynamical systems. In each case simple local rules are shown to yield interesting collective global behavior. (a) We introduce a mechanism for the evolution of growing small world networks. We demonstrate that purely local connection rules, when coupled with network growth, can result in(More)
We present a reliable, easy to implement algorithm to generate a set of highly reliable overlaps based on identifying repeat k-mers. Our method is coverage independent. Whereas traditionally reads have been trimmed to have expected error rates of 2%, we find our error correction allows extending usable sequence in reads to 16% trimming. We use a version of(More)
The functional status of the dopaminergic system following striatal excitotoxic lesions was studied in living baboons by positron emission tomography (PET) using 6-[18F]fluoro-L-dopa as specific tracer for the presynaptic dopaminergic terminals and [76Br]bromolisuride as selective dopamine D2-receptor marker. The glutamate receptor agonist ibotenic acid(More)
The binding of the 11C-labeled benzodiazepine antagonist Ro 15-1788 (flumazenil) was measured in the neocortex of live Papio papio baboons by positron emission tomography. This allowed us to calculate in vivo (i.e., at physiological temperature, neurotransmitters concentrations, and ionic environment) the apparent density of available benzodiazepine(More)
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