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Receptor interacting protein 140 (RIP140) interacts with retinoic acid receptor (RAR) and retinoid X receptor (RXR) constitutively, but hormone binding enhances this interaction. The ligand-independent interaction is mediated by the amino and central regions of RIP140 which contain a total of nine copies of the LXXLL motif, whereas the agonist-induced(More)
Purpose : The purpose was to investigate vitrification of human blastocysts using the cryoloop. Methods : Thirteen couples elected to have blastocysts cryopreserved via vitrification (N = 54 blastocysts). Embryos were exposed to two vitrification solutions, pipetted onto the cryoloop then plunged into liquid nitrogen. On the day of embryo replacement,(More)
OBJECTIVES Describe health-related quality of life (HRQoL) of former Canadian Forces (CF) men and women in uniform (Veterans) after transition to civilian life, and compare to age- and sex-adjusted Canadian norms. METHODS The 2010 Survey on Transition to Civilian Life was a national computer-assisted telephone survey of CF Regular Force personnel who(More)
CONTEXT Aperio Technologies, Inc (Vista, California) provides a new immunohistochemistry (IHC) HER2 Image Analysis (IA) system that allows tuning of the intensity thresholds of the HER2/ neu scoring scheme to adapt to the staining characteristics of different reagents. OBJECTIVE To compare the trainable IHC HER2 IA system for different reagents to(More)
A multisite study was conducted to assess the performance of the Aperio digital pathology system (Aperio Technologies, Vista, CA) for reading estrogen receptor (ER) and progesterone receptor (PR) slides on a computer monitor. A total of 520 formalin-fixed breast tissue specimens were assayed at 3 clinical sites for ER and PR (260 each). Percentage and(More)
Can J Emerg Med 2003;5(5):343-7 These Recommendations were approved by the CAEP Board June 8, 2003. *Chief, Schwartz–Reisman Emergency Centre, Mount Sinai Hospital, Toronto, Ont.; and Assistant Professor, Department of Family and Community Medicine, University of Toronto, Toronto, Ont. †Chief, Emergency Department, Queen Elizabeth Hospital, Charlottetown,(More)
The performance of a novel dry powder inhaler designed to deliver exceptionally high doses was investigated using pumactant as a model powder. Pumactant (a synthetic lung surfactant consisting of a phospholipid mixture), with a 90th percentile particle size of 2.92 microm is highly cohesive, has a high moisture affinity (6.2% w/w at 45% RH), and is(More)
We report here the genome sequences of three Flavobacterium psychrophilum strains causing a bacterial coldwater disease (BCWD) outbreak, isolated from infected rainbow trout from hatcheries in Montana and South Dakota. The availability of these virulent outbreak-causing strain genome sequences will help further understand the pathogenesis of BCWD.
Object-oriented concepts such as reuse and encapsulation offer many benefits to application development, particularly in managing complexity and change. All the benefits of OO that apply to the client can apply equally well to the server. However, until recently, these concepts have proven to benefit only the client side. Could there be any intrinsic or(More)