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BACKGROUND Osteopontin previously has been shown to be expressed in the early notochord and rostral hindbrain during formation of the rat neuraxis. Both of these sites are known to have important organizing capacities associated with the expression of a number of transcription factors and secreted signaling molecules. Thus multiple types of molecules are(More)
Companies are seeking ways to track, measure, and compare the sustainability of their manufactured products and operations. Regulations already require companies to track GHG emissions. Some are embracing the challenge by trying to establish verifiably sustainable business models. For them it will become important to adopt recognized best practices. This(More)
The rapid development of therapeutic oligonucleotides (ONs) has created a need for in-depth characterization of ONs, beyond previous requirements. The natural migration to LC-MS requires the use of chromatography with MS-compatible eluents to introduce the large, highly charged biopolymers into the mass spectrometer. Most frequently this employs ion-pair(More)
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