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Data annotations are an important kind of meta-data that occur in the form of externally assigned descriptions of particular features in Web accessible documents. Such metadata are eventually used in data retrieval tasks on heterogeneous, possible distributed Web-accessible documents. In this paper, we present the model and realization of an annotation(More)
The peptide endothelin 3 (EDN3) is essential for normal neural crest development in vivo, and is a potent mitogen for quail truncal crest cells in vitro. It is not known which subpopulations of crest cells are targets for this response, although it has been suggested that EDN3 is selective for melanoblasts. In the absence of cell markers for different(More)
Ras is a major mediator of PE (phorbol ester) effects in mammalian cells. Various mechanisms for PE activation of Ras have been reported [Downward, Graves, Warne, Rayter and Cantrell (1990) Nature (London) 346, 719-723; Shu, Wu, Mosteller and Broek (2002) Mol. Cell. Biol. 22, 7758-7768; Roose, Mollenauer, Gupta, Stone and Weiss (2005) Mol. Cell. Biol. 25,(More)
The transcription factor growth factor independence 1 (Gfi1) and the growth factor granulocyte colony-stimulating factor (G-CSF) are individually essential for neutrophil differentiation from myeloid progenitors. Here, we provide evidence that the functions of Gfi1 and G-CSF are linked in the regulation of granulopoiesis. We report that Gfi1 promotes the(More)
ii DEDICATION For my grandfather iii ACKNOWLEDGEMENTS Above all I would like to thank Kevin Gurney for his generous and astute supervision. Many thanks are also due to Jackie Andrade, for supervision and advice, especially in the early stages; to the Basal Ganglia research group, for support of all kinds (especially Mark Humphries and Ric Wood); Neil Porter(More)
The transcription factor Gfi1 and the growth factor G-CSF are individually essential for neutrophil differentiation from myeloid progenitors, since mutant mice lacking Gfi1 or G-CSF/G-CSF receptor are severely neutropenic. Here, we provide evidence that the functions of Gfi1 and G-CSF are linked in the regulation of granulopoiesis. We report that Gfi1(More)
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