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In an effort to identify novel cholinesterase candidates for the treatment of Alzheimer's disease (AD), a diverse array of potentially bioactive compounds including triazolothiadiazoles (4a-h and 5a-f) and triazolothiadiazines (6a-h) was obtained in good yields through the cyclocondensation reaction of 4-amino-5-(pyridin-3-yl)-4H-1,2,4-triazole-3-thiol (3)(More)
An amine-functionalized succinyl chitosan and an oxidized dextran were synthesized and mixed in aqueous solution to form an in situ chitosan/dextran injectable, surgical hydrogel for adhesion prevention. Rheological characterization showed that the rate of gelation and moduli were tunable based on amine and aldehyde levels, as well as polymer(More)
N-(2-Bromoethyl)-4-piperidino-1,8-naphthalimide, C(19)H(19)BrN(2)O(2), (I), and N-(3-bromopropyl)-4-piperidino-1,8-naphthalimide, C(20)H(21)BrN(2)O(2), (II), are an homologous pair of 1,8-naphthalimide derivatives. The naphthalimide units are planar and each piperidine substituent adopts a chair conformation. This study emphasizes the importance of(More)
2-(4-Chloro-phen-yl)-2-oxoethyl 3-bromo-benzoate, C15H10BrClO3, was synthesized in a single-step reaction by condensation of 3-bromo-benzoic acid with 2-bromo-1-(4-chloro-phen-yl)ethanone in di-methyl-formamide in the presence of tri-ethyl-amine as a catalyst. The structure consists of an aryl ketone moiety linked to an aryl ester unit by a methyl-ene(More)
Resource Group) provided immeasurable support and assistance with database management, technology (STRATUM and PDAs), editing and formatting. Van Wieren (Tree Trust) trained and coordinated the volunteers and provided a welcome environment while in Minnesota. Resources) were also instrumental in training the volunteers. Jim Baldwin (USDA Forest Service) and(More)
Electroactive metallocene polymers are of interest due to the possibility that they offer a muscle-like response, and in gel systems very large volume changes are possible. The ferrocenyl moiety exhibits physical and electrochemical stability of the neutral and oxidized forms and could be a candidate for use as the redox-active group in these materials. The(More)
The mol-ecule of the title compound [systematic name: 2-(4-tert-butyl-benz-yl)isoindoline-1,3-dione], C(19)H(19)NO(2), is V-shaped with a dihedral angle of 74.15 (7)° between the mean planes of the phthalimide unit and the benzene ring. The methyl groups of the tert-butyl substituent are disordered over two sets of positions, with an occupancy ratio of(More)
Trisaccharides, methyl alpha-L-fucopyranosyl-(1-->2)-beta-D-galactopyranosyl-(1-->2)-alpha-D-xy lopyranoside and methyl alpha-L-fucopyranosyl-(1-->2)-beta-D-galactopyranosyl-(1-->2)-beta-D-xyl opyranoside, which are related to the side chain of xyloglucan have been synthesised. The beta-galactopyranosyl linkage of each was constructed using silver(More)
In the title compound, C(15)H(20)O(4)S, a dioxolane ring is fused to the pyran ring of the sugar which carries a thio-phenyl substituent on the anomeric C atom. The dioxolane ring adopts an envelope conformation and the pyran ring system a distorted (4)C(1) chair. The structure is stabilized by O-H⋯O hydrogen bonds, forming centrosymmetric dimers that(More)
In the title compound, [Ni(C(5)H(5))(C(5)H(7)O)(C(18)H(15)P)], the molecule adopts the expected half-sandwich structure with no unusual metal-ligand distances. No classical hydrogen bonds are found in the structure; instead, the OH group of the butynol unit is involved in an unusual O-H...pi interaction with the C[triple-bond]C group of an adjacent(More)