Learn More
Etoposide is commonly used in a variety of malignancies. A well known but rare toxicity are hypersensitivity reactions, usually manifested by chest discomfort, dyspnoea, bronchospasm and hypotension. We report the details of a patient who developed hypersensitivity reactions to intravenous etoposide, but subsequently tolerated the administration of(More)
The usefulness of pharmacokinetically guided individualisation of drug therapy will depend, among other things, on the quality of the analytical and pharmacokinetic methods used. We surveyed the quality of analytical and pharmacokinetics methodology and reporting in a literature search of the oncology literature from 1987 to 1992, using the Medline(More)
Sir-With respect to the article entitled 'The Influence of Serum Methotrexate Concentrations and Drug Dosage on Outcome In Childhood Acute Lymphoblastic Leukaemia', we believe basic pharmacokinetic principles have not been correctly applied. The apparent lack of correlation described therein may be due to the method used to calculate methotrexate clearance.(More)
The issue of medication safety is highly significant when anti-cancer therapy is used as a treatment modality due to the high potential for harm from these agents and the disease context in which they are being used. These guidelines provide recommendations on the safe prescribing, dispensing and administration of chemotherapy and related agents used in the(More)
  • 1