Jim S. Briggs

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We have previously reported that loss-of-function mutations in the cathepsin C gene (CTSC) result in Papillon-Lefèvre syndrome, an autosomal recessive condition characterized by palmoplantar keratosis and early-onset, severe periodontitis. Others have also reported CTSC mutations in patients with severe prepubertal periodontitis, but without any skin(More)
Increasingly, applications of technology are being developed to provide care to elderly and vulnerable people living alone. This paper looks at using sensors to monitor a person's wellbeing. The paper attempts to recognise and distinguish falling, sitting and walking activities from accelerometer data. Fast Fourier Transformation (FFT) is used to extract(More)
Radio-frequency Identification (RFID) offers a potentially flexible and low cost method of locating objects and tracking people within buildings. RFID systems generally require less infrastructure to be installed than other solutions but have their own limitations. As part of an assisted living system, RFID tools may be useful to locate lost objects,(More)
INTRODUCTION The Royal College of Physicians (RCPL) National Early Warning Score (NEWS) escalates care to a doctor at NEWS values of ≥5 and when the score for any single vital sign is 3. METHODS We calculated the 24-h risk of serious clinical outcomes for vital signs observation sets with NEWS values of 3, 4 and 5, separately determining risks when the(More)
AIM OF STUDY To build an early warning score (EWS) based exclusively on routinely undertaken laboratory tests that might provide early discrimination of in-hospital death and could be easily implemented on paper. MATERIALS AND METHODS Using a database of combined haematology and biochemistry results for 86,472 discharged adult patients for whom the(More)
OBJECTIVE To compare the ability of medical emergency team criteria and the National Early Warning Score to discriminate cardiac arrest, unanticipated ICU admission and death within 24 hours of a vital signs measurement, and to quantify the associated workload. DESIGN Retrospective cohort study. SETTING A large U.K. National Health Service District(More)
INTRODUCTION Sicker patients generally have more vital sign assessments, particularly immediately before an adverse outcome, and especially if the vital sign monitoring schedule is driven by an early warning score (EWS) value. This lack of independence could influence the measured discriminatory performance of an EWS. METHODS We used a population of(More)
In this paper, we describe our experience of designing a telecare product for the elderly. This is a collaborative project involving Passivsystems Ltd and the Centre for Healthcare Modelling and Informatics at the University of Portsmouth. The research aims at adapting Passivsystems' existing in-home hub so that it is capable of providing a telecare service(More)
It is well known that Logistic Regression is the gold standard method for predicting clinical outcome, especially predicting risk of mortality. In this paper, the Decision Tree method has been proposed to solve specific problems that commonly use Logistic Regression as a solution. The Biochemistry and Haematology Outcome Model (BHOM) dataset obtained from(More)