Jim R Cooper

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A speculative hypothesis is presented which links the late development of modern concepts of schizophrenia with social and familial effects of industrialization. It is suggested that the social and family structures found historically in pre-industrial societies and currently in developing countries exert a comparatively benign effect upon patients with(More)
To assess the hypothesis that thiamine is directly involved in the permeability changes at the sodium channel during nerve conduction, the effects of thiamine antagonists on lobster giant axon resting and action potentials were determined. Thiamine antimetabolites, in millimolar concentrations, reversibly decreased the maximum rate of rise and amplitude of(More)
Thiamine antimetabolites were externally applied to voltage clamped squid giant axons to investigate the possible role of thiamine in nerve conduction. Phenylthiazinothiamine, in concentrations as low as 250 muM, reduced peak early current and steady-state current, with the depression of the former being two to five times greater than that of the latter.(More)