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Dynamic turnover of the spindle is a driving force for chromosome congression and segregation in mitosis. Through a functional genomic analysis, we identify DDA3 as a previously unknown regulator of spindle dynamics that is essential for mitotic progression. DDA3 depletion results in a high frequency of unaligned chromosomes, a substantial reduction in(More)
Through a functional genomic screen for mitotic regulators, we identified hepatoma up-regulated protein (HURP) as a protein that is required for chromosome congression and alignment. In HURP-depleted cells, the persistence of unaligned chromosomes and the reduction of tension across sister kinetochores on aligned chromosomes resulted in the activation of(More)
The checkpoint protein Chfr delays entry into mitosis, in the presence of mitotic stress (Scolnick, D.M., and T.D. Halazonetis. 2000. Nature. 406:430-435). We show here that Chfr is a ubiquitin ligase, both in vitro and in vivo. When transfected into HEK293T cells, Myc-Chfr promotes the formation of high molecular weight ubiquitin conjugates. The ring(More)
OBJECTIVE To test the hypothesis that obstructive sleep apnea (OSA) is a risk factor for development of postoperative atrial fibrillation (POAF) after cardiac surgery. DESIGN Retrospective analysis. SETTING Single-center university hospital. PARTICIPANTS Five hundred forty-five patients in sinus rhythm preoperatively undergoing coronary artery bypass(More)
OBJECTIVES Recent analyses establish that heart transplantation is increasing among adults with congenital heart disease (ACHD), but the effects of pretransplant mechanical circulatory support (MCS) on perioperative and post-transplant outcomes have not been examined in the ACHD population. METHODS Scientific Registry of Transplant Recipients data on all(More)
This study develops a framework for stress testing the credit exposures of Hong Kong's retail banks to macroeconomic shocks. The analysis suggests a significant relationship between the default rates of bank loans and key macroeconomic factors, including Hong Kong's GDP, interest rates and property prices and the Mainland's GDP. Macro stress testing is(More)
View the peer-reviewed version (peerj.com/articles/245), which is the preferred citable publication unless you specifically need to cite this preprint. and mortality of cardiothoracic surgery in patients with a do-not-resuscitate Perioperative morbidity and mortality of cardiothoracic surgery in patients with a do-not-resuscitate order. Background:(More)
Background. Do-not-resuscitate (DNR) orders are often active in patients with multiple comorbidities and a short natural life expectancy, but limited information exists as to how often these patients undergo high-risk operations and of the perioperative outcomes in this population. Methods. Using comprehensive inpatient administrative data from the Public(More)
BACKGROUND Guidelines recommend that adults with congenital heart disease (CHD) undergo noncardiac surgery in regionalized centers of expertise, but no studies have assessed whether this occurs in the United States. We hypothesized that adults with CHD are less likely than children to receive care at specialized CHD centers. METHODS Using a comprehensive(More)
This paper looks into how the liquidity of the Hong Kong stock market has evolved since the Asian financial crisis, and examines the determinants of changes in liquidity. Various conventional liquidity indicators are constructed for the study period from 1997 to June 2001. They show that, having deteriorated during the Asian financial crisis and the Russian(More)
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