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In this first of two articles, we discuss some issues surrounding the dissolution rate enhancement of poorly-soluble active ingredients micronized into nano-particles using several supercritical fluid particle design processes including rapid expansion of supercritical solutions (RESS), supercritical anti-solvent (SAS) and particles from gas-saturated(More)
In this second of two articles, we show that several supercritical processes have been developed to prepare composite particles of poorly soluble active ingredients. Microencapsulation, cyclodextrin inclusion and impregnation allow to incorporate poorly soluble materials in fast-dissolving hydrophilic excipients, leading to promising results in terms of(More)
Experiments were conducted to quantify the impact of satellite data (Earth Observations from Space—EOS) on the determination of current and future atmospheric state. These experiments have examined two different time periods using two different operational forecast models. The results show that, in the southern hemisphere, the accuracy of a no-satellite(More)
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