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Acute diabetes with ketosis was induced in rats by intraperitoneal streptozotocin and also a milder form of diabetes without ketosis by injecting less of the drug. The acutely diabetic rats were killed 72h after injection and the others after either 2 or 13 weeks. Free and lipid myo-inositol was then measured in various tissues and body fluids by g.l.c. of… (More)
An active transport system maintains myo-inositol in the brain at a much higher concentration than in the blood. Free and total lipid inositol has been analysed in samples of normal human anterior temporal cortex of different ages. At age 20 the concentration of inositol was 60 mumols/g protein, and it fell steadily to half that concentration at age 90.… (More)
Samples of brain anterior temporal cortex from 17 patients with Alzheimer's disease and 18 age-matched controls have been analysed for myo-inositol and the three phosphoinositides. There was significantly less phosphatidylinositol in the Alzheimer samples (1.36 mumol/g wet weight) than in the controls (2.28 mumol/g). The concentrations of… (More)
myo-Inositol transport by a viable rat sciatic-nerve preparation is described. Such 'endoneurial' nerve preparations accumulated myo-inositol by an energy-dependent saturable system. Streptozotocin-diabetes reduced myo-inositol transport into sciatic nerve by approx. 40%. Elevated medium glucose concentration reduced myo-inositol transport into control… (More)
Sciatic nerves removed post-mortem from diabetic patients and normal subjects were analysed by gas chromatography for glucose, fructose, sorbitol and myo-inositol. The concentrations of free and lipid inositol were significantly lower in nerves from the diabetic than from the control group. Concentrations of glucose, fructose and sorbitol were higher in the… (More)
The secretion of catecholamines and the labelling of phospholipids with 32Pi has been studied in slices of bovine adrenal medulla. Both nicotinic and muscarinic drugs provoked catecholamine secretion, but only muscarinic activation was accompanied by the increased labelling of phosphatidylinositol and phosphatidic acid.