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Eight community trials were carried out by the Onchocerciasis Control Programme in West Africa to determine the safety of the new microfilaricide ivermectin during large-scale treatment of onchocerciasis. The trial areas were located in eight different countries and varied greatly in endemicity level; a total of 50,929 persons were treated and monitored for(More)
The Onchocerciasis Control Programme in West Africa recently extended its operation to Guinea, Guinea-Bissau, the western part of Mali, Senegal and Sierra Leone. To estimate the number of people infected and blinded by the disease and to determine its distribution and severity in the extension area, 215 villages were selected, using a stratified random(More)
Detailed epidemiological mapping of three isolated foci of hyperendemic blinding onchocerciasis was undertaken in three West African countries as part of community trials of ivermectin, a new microfilaricide for the treatment of human onchocerciasis. The results show that the geographical distribution of the prevalence and intensity of onchocerciasis(More)
A community trial of the microfilaricide ivermectin undertaken in an hyperendemic focus of blinding onchocerciasis in Ghana. One objective was to investigate the safety of this new drug when used in mass treatments. 14,911 persons (61.5% of the census population) were treated with ivermectin. Of these, 15% reported with adverse reactions which were(More)
Detailed epidemiological mapping of eight river basins was conducted in four West African countries as part of an effort to identify the communities at risk of onchocercal blindness to guide a programme of large scale ivermectin distribution, attempting control of eye disease. The results show a surprising variability of pattern in the geographical(More)
Urban watersheds and receiving waters are adversely affected by urbanization that increases risk of flooding and, in the same time, reduces the chemical, physical (habitat) and biological integrity of the affected water bodies. Restoration of ecological integrity and flood control objectives in the past were conflicting, often to a degree that flood control(More)