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Summary form only given. XML is gaining widespread acceptance as a standard for storing and transmitting structured data. One of the drawbacks of XML is that it is quite verbose: an XML representation of a set of data can easily be ten times as large as a more economical representation of the data. To overcome this limitation, we present a compression(More)
A possible role for cyclic GMP as a mediator of the endothelium-dependent relaxation of rabbit aorta by acetylcholine has been investigated using rabbit aortic rings with and without intact endothelium. In the presence of intact endothelial cells, acetylcholine caused marked increases in tissue levels of cyclic GMP accompanied by relaxation of the muscles.(More)
This paper introduces an automated computer- assisted system for the diagnosis of cervical intraepithelial neoplasia (CIN) using ultra-large cervical histological digital slides. The system contains two parts: the segmentation of squamous epithelium and the diagnosis of CIN. For the segmentation, to reduce processing time, a multiresolution method is(More)
Cervical virtual slides are ultra-large, can have size up to 120K x 80K pixels. This paper introduces an image segmentation method for the automated identification of Squamous epithelium from such virtual slides. In order to produce the best segmentation results, in addition to saving processing time and memory, a multiresolution segmentation strategy was(More)
Ten minutes after KCl-depolarization of rat myometrial strips, at which time the muscles were in a state of sustained contracture, tissue levels of adenosine 3',5'-cyclic monophosphate (cyclic AMP) were increased by approximately 40% over relaxed controls, and levels of guanosine 3',5'-cyclic monophosphate (cyclic GMP) were decreased by 40%. At this point(More)
A novel cyclic GMP-lowering agent, LY83583(6-anilino-5,8-quinolinedione), was used to investigate the possibility that increases in myocardial cyclic GMP levels are responsible for the negative inotropic effects of cholinergic agonists. Concentrations of carbachol from 0.3 to 3 microM elevated cyclic GMP levels in electrically paced rabbit atrial strips by(More)
The role of cyclic AMP (cAMP) in the control of vascular smooth muscle tension was examined by comparing the effects of prostacyclin (PGI2) on tension and cAMP levels in helical strips of bovine coronary arteries and in rabbit aortic rings, both denuded of endothelium. In bovine coronary arteries, PGI2 elevated cAMP levels and relaxed the muscles. The(More)
  • J Diamond
  • Canadian journal of physiology and pharmacology
  • 1987
Elevation of cyclic GMP by muscarinic agonists has been suggested to be responsible for the negative inotropic effects of these agents in cardiac muscle, and for the endothelium-dependent relaxation caused by these agents in vascular smooth muscle. These relationships were studied by monitoring the effects of muscarinic agonists on tension and cyclic GMP(More)