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  • Toshiyuki Mori, Barry R. O’Keefe, +8 authors Michael R. Boyd
  • Biology, Medicine
  • Journal of Biological Chemistry
  • 2005 (First Publication: 11 March 2005)
  • Griffithsin (GRFT), a novel anti-HIV protein, was isolated from an aqueous extract of the red alga Griffithsia sp. The 121-amino acid sequence of GRFT has been determined, and biologically activeContinue Reading
  • Xin Chen, Lu Yang, +5 authors O. M. Zack Howard
  • Medicine, Biology
  • Antimicrobial agents and chemotherapy
  • 2003 (First Publication: 1 September 2003)
  • Shikonin is a major component of zicao (purple gromwell, the dried root of Lithospermum erythrorhizon), a Chinese herbal medicine with various biological activities, including inhibition of humanContinue Reading
  • Monte S. Meltzer, Mitsuru Niihariryo B Nakamura, Brian David Hansen, Jim A. Turpin, D. Chester Kalter, Howard E. Gendelman
  • Biology, Medicine
  • AIDS research and human retroviruses
  • 1990 (First Publication: 1 August 1990)
  • Although macrophages are major targets for human immunodeficiency virus (HIV) infection in vivo, study of HIV-macrophage interactions in vitro was hindered because many laboratory strains of HIVContinue Reading
  • Jim A. Turpin, Sara J Terpening, +5 authors W. G. Rice
  • Medicine, Biology
  • Journal of virology
  • 1996 (First Publication: 1 September 1996)
  • The Cys-Xaa2-Cys-Xaa4-His-Xaa4-Cys zinc fingers of retroviral nucleocapsid proteins are prime antiviral targets because of conservation of the Cys and His chelating residues and the absoluteContinue Reading
  • Mingjun Huang, Andrew Maynard, +4 authors William Gorham Rice
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 1998 (First Publication: 1 April 1998)
  • Agents that target the two highly conserved Zn fingers of the human immunodeficiency virus (HIV) nucleocapsid p7 (NCp7) protein are under development as antivirals. These agents covalently modifyContinue Reading