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Hypothalamic neuron circuits regulating energy balance are highly plastic and develop in response to nutrient and hormonal cues. To identify processes that might be susceptible to gestational influences in mice, we characterized the ontogeny of proopiomelanocortin (POMC) and neuropeptide Y (NPY) cell populations, which exert opposing influences on food(More)
Supplemental Material Supplementary Methods Animals Animals were housed in temperature controlled rooms at 21 °C and subject to a 12 h light-dark cycle. Mice had ad libitum access to standard chow diet (Lab Diet: PicoLab Rodent Diet 5053) and water. C57BL/6 and (ROSA)26Sor-EGFP reporter (R26-GFP) mice were obtained from the Jackson Laboratory and bred at(More)
The central glucagon-like peptide-1 (GLP-1) system has been implicated in the control of feeding behavior. Here we explore GLP-1 mediation of the anorexic response to administration of systemic LPS and address the relative importance of caudal brain stem and forebrain GLP-1 receptor (GLP-1-R) for the mediation of the response. Fourth-intracerebroventricular(More)
Research Summary: Our research is focused on characterizing two distinct developmental processes that could, in principle, impart persistent influences on obesity-related outcomes: (1) maternal influences on the specification of functionally antagonistic neuronal populations in the embryonic hypothalamus, and (2) the establishment of defended set-points for(More)
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