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BACKGROUND Although implantable cardioverter-defibrillator (ICD) therapy reduces mortality in moderately symptomatic heart failure patients with an ejection fraction <or=35%, many such patients do not require ICD shocks over long-term follow-up. METHODS AND RESULTS Using a modification of a previously validated risk prediction model based on routine(More)
BACKGROUND The ratio of digit lengths is fixed in utero, and may be a proxy indicator for prenatal testosterone levels. METHODS We analysed the right-hand pattern and prostate cancer risk in 1524 prostate cancer cases and 3044 population-based controls. RESULTS Compared with index finger shorter than ring finger (low 2D : 4D), men with index finger(More)
To describe the adaptive pattern of cortically generated auditory evoked potentials elicited by repeated stimuli via cochlear implants (CIs), the late auditory evoked potential (LAEP) was collected from nine postlingually deafened adult CI users. Tone bursts were presented in 30 trains consisting of 10 tone bursts each, with inter-stimulus intervals (ISIs)(More)
BACKGROUND In the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT), implantable cardioverter-defibrillator (ICD) therapy significantly reduced all-cause mortality rates compared with medical therapy alone in patients with stable, moderately symptomatic heart failure, whereas amiodarone had no benefit on mortality rates. We examined long-term economic(More)
BACKGROUND In patients with heart failure, rates of clinically apparent stroke range from 1.3% to 3.5% per year. Little is known about the incidence and risk factors in the absence of atrial fibrillation. In the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT), 2521 patients with moderate heart failure were randomized to receive amiodarone, implanted(More)
BACKGROUND The Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT) demonstrated that implantable cardioverter-defibrillator (ICD) therapy reduces all-cause mortality in patients with New York Heart Association class II/III heart failure and a left ventricular ejection fraction < or =35% on optimal medical therapy. Whether ICD therapy reduced sudden death(More)
To determine the role of aldosterone in the regulation of blood pressure (BP) in obese adolescents, supine and 2-hour upright plasma renin activity (PRA), and aldosterone and cortisol were measured in 10 nonobese and 30 obese adolescents before and after a 20-week weight loss program. The obese adolescents had significantly higher supine and 2-hour upright(More)
BACKGROUND This study provides a detailed description of the time course of amplitude and latency in the auditory late response (ALR) elicited by repeated tone bursts. RESEARCH DESIGN Tone bursts (50 and 80 dB SPL) were presented via insert earphones in trains of ten with interstimulus intervals (ISIs) of 0.7 and 2 msec and an intertrain interval of 15(More)
BACKGROUND The hypothesis that thrombin mediates the formation of neointimal vascular lesions at sites of mechanical vascular injury has been tested in baboons by measurement of the effects of hirudin delivered by retrovirus-transduced hirudin-secreting vascular endothelial cells (ECs) lining surgically implanted arterial vascular grafts (AVGs). METHODS(More)
Selenium concentrations in the serums of 17 acutely ill Legionnaires' disease patients were significantly lower than in their matching convalescent-phase serums. This trend was not observed in ten similarly paired samples of serum from control patients with pneumonia. There were no significant differences in the concentrations of nickel, copper, bromine,(More)