Jill Ireland

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OBJECTIVE A retrospective analysis was performed to assess gait in individuals with a long history of posterior knee instability. DESIGN Descriptive study. BACKGROUND There are few studies in the literature concerning evaluation of the biomechanics of the knee in patients with knee posterior instability. METHODS Nine individuals with posterior knee(More)
OBJECTIVE To investigate the in vivo activity of poly(sodium 4-styrene sulfonate) (T-PSS) gel formulations as topical microbicides. METHODS The ability of the gel formulations to reduce the incidence of infection when applied prior to pathogen challenge was examined in mouse models of vaginal herpes simplex type 2 (HSV-2) and Chlamydia trachomatis(More)
Prevention of sexually transmitted infections is a priority in developed and developing countries. One approach to prevention is the use of topical microbicides, and one promising approach is the use of dendrimers, highly branched macromolecules synthesized from a polyfunctional core. Three new dendrimer products developed to provide stable and(More)
There is increasing interest in the use of topical microbicides to help prevent the spread of sexually transmitted diseases (STD). Undecylenic acid (UA), a monosaturated fatty acid, is the active ingredient in a number of over-the-counter (OTC) antifungal spray powders, that also exhibits in vitro antibacterial and antiviral activity, including herpes(More)
Our understanding of the pathogenesis of acyclovir (ACV)-resistant herpes simplex virus (HSV) is limited, especially with regard to reactivation and recurrent disease. To further explore the pathogenesis of ACV-resistant HSV-2 viruses, we used the guinea pig model of genital HSV-2 infection to evaluate several ACV-resistant isolates of both thymidine kinase(More)
The amount of apparent leg-length inequality attributable to given angles of hip adduction/abduction has been expressed quantitatively. The inequality is related to the sine of the angle of adduction/abduction and the distance between the centers of the femoral heads. In a study of 50 adults, the mean figure for this distance in men and women was 18.6 cm.(More)
Major changes in the morphology of the urinary bladder were observed during the transition from yolk-sac to feeding larval stages of herring, in particular bladder volume increased almost sixfold. Initially, the urine flowed into the hindgut, but within days of hatching a separate urinary duct, leading to the exterior, had formed. Micturation was(More)
Vaginal gel formulations containing the naphthalene sulfonate polymer PRO 2000 are being developed as topical microbicides to protect against infection with sexually transmitted disease (STD) pathogens. A mouse model was used to determine whether PRO 2000 could protect against genital herpes in vivo. Animals received a single intravaginal application of 15(More)