Learn More
BACKGROUND Sudden death from cardiac causes remains a leading cause of death among patients with congestive heart failure (CHF). Treatment with amiodarone or an implantable cardioverter-defibrillator (ICD) has been proposed to improve the prognosis in such patients. METHODS We randomly assigned 2521 patients with New York Heart Association (NYHA) class II(More)
BACKGROUND Patients with heart failure who receive an implantable cardioverter-defibrillator (ICD) for primary prevention (i.e., prevention of a first life-threatening arrhythmic event) may later receive therapeutic shocks from the ICD. Information about long-term prognosis after ICD therapy in such patients is limited. METHODS Of 829 patients with heart(More)
BACKGROUND Although implantable cardioverter-defibrillator (ICD) therapy reduces mortality in moderately symptomatic heart failure patients with an ejection fraction <or=35%, many such patients do not require ICD shocks over long-term follow-up. METHODS AND RESULTS Using a modification of a previously validated risk prediction model based on routine(More)
BACKGROUND The Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT) demonstrated that implantable cardioverter-defibrillator (ICD) therapy reduces all-cause mortality in patients with New York Heart Association class II/III heart failure and a left ventricular ejection fraction < or =35% on optimal medical therapy. Whether ICD therapy reduced sudden death(More)
OBJECTIVES This study investigated whether defibrillation threshold (DFT) testing during implantable cardioverter-defibrillator (ICD) implantation predicts clinical outcomes. BACKGROUND Defibrillation testing is often performed during insertion of ICDs to confirm shock efficacy. There are no prospective data to suggest that this procedure improves(More)
Twenty thoracic aortas were obtained post-mortem from subjects between the ages of 14 and 90 years who had previously been recorded as normotensive. Full wall thickness samples of 1 cm diameter were taken at six sites between heart valve and diaphragm. Lipid-free dry weight (mg per sample) and amounts (mg per sample) and concentrations (mg/mg dry weight) of(More)
BACKGROUND The most common location of out-of-hospital sudden cardiac arrest is the home, a situation in which emergency medical services are challenged to provide timely care. Consequently, home use of an automated external defibrillator (AED) might offer an opportunity to improve survival for patients at risk. METHODS We randomly assigned 7001 patients(More)
OBJECTIVES To compare pain and discomfort ratings of female patients undergoing urethral catheterization randomized to topical application of plain lubricant versus lidocaine gel prior to the procedure. METHODS This was a prospective, randomized, double-blind study involving female patients requiring urethral catheterization at an urban university-based(More)
OBJECTIVES The aim of this study was to examine rapid-rate nonsustained ventricular tachycardia (RR-NSVT) during routine implantable cardioverter-defibrillator (ICD) evaluation in patients with heart failure and its relationship to outcomes. BACKGROUND The clinical implications of RR-NSVT identified during routine ICD interrogation are unclear. In this(More)