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In yeasts and worms, KASH (Klarsicht/ANC-1/Syne/homology) domain and SUN (Sad-1/UNC-84) domain nuclear envelope (NE) proteins play a crucial role in meiotic chromosome movement and homologue pairing. However, although the vertebrate SUN domain protein SUN1 is involved in these processes, its partner has remained identified. Based on subcellular localization(More)
We identify a new mammalian cohesin subunit, RAD21-like protein (RAD21L), with sequence similarity to RAD21 and REC8. RAD21L localizes along axial elements in early meiotic prophase, in a manner that is spatiotemporally different to either REC8 or RAD21. Remarkably, RAD21L and REC8 have symmetrical, mutually exclusive localization on the not-yet-synapsed(More)
A consolidated memory can be transiently destabilized by memory retrieval, after which memories are reconsolidated within a few hours; however, the molecular substrates underlying this destabilization process remain essentially unknown. Here we show that at lateral amygdala synapses, fear memory consolidation correlates with increased surface expression of(More)
Protein kinases play important roles in regulating signal transduction in eukaryoticcells. Due to evolutionary conserved binding sites in the catalytic domain of thekinases, most inhibitors that target these sites promiscuously inhibit multiplekinases. Quantitative analysis can reveal complex and unexpected interactions betweenprotein kinases and kinase(More)
The objectives of this study were to investigate the status of vitamin D in Korean adolescents and to determine the association between serum 25-hydroxyvitamin D (25(OH)D) concentration and consumption frequencies of vitamin D food sources by season (June to November and December to May). The subjects were 1,579 adolescents aged 12-18 years participating in(More)
Acute myeloid leukemia (AML) remains a therapeutic challenge despite increasing knowledge about the molecular origins of the disease, as the mechanisms of AML cell escape from chemotherapy remain poorly defined. We hypothesized that AML cells are addicted to molecular pathways in the context of chemotherapy and used complementary approaches to identify(More)
Private Set Intersection (PSI) protocols allow one party (" client ") to compute an intersection of its input set with that of another party (" server "), such that the client learns nothing other than the set intersection and the server learns nothing beyond client input size. Prior work yielded a range of PSI protocols secure under different cryptographic(More)
Public key based authentication and key exchange protocols are not usually designed with privacy in mind and thus involve cleartext exchanges of identities and certificates before actual authentication. In contrast, an Affiliation-Hiding Authentication Protocol, also called a Secret Handshake, allows two parties with certificates issued by the same(More)
As the global society becomes more interconnected and more privacy-conscious, communication protocols must balance access control with protecting participants' privacy. A common current scenario involves an authorized party (client) who needs to retrieve sensitive information held by another party (server) such that: (1) the former only gets the information(More)