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Transient receptor potential channels are important mediators of thermal and mechanical stimuli and play an important role in neuropathic pain. The contribution of hereditary variants in the genes of transient receptor potential channels to neuropathic pain is unknown. We investigated the frequency of transient receptor potential ankyrin 1, transient(More)
Granulocytes are pivotal regulators of tissue injury. However, the transcriptional mechanisms that regulate granulopoiesis under inflammatory conditions are poorly understood. Here we show that the transcriptional coregulator B cell leukemia/lymphoma 3 (Bcl3) limits granulopoiesis under emergency (i.e., inflammatory) conditions, but not homeostatic(More)
Multiple studies have shown a link between chronic inflammation and lung tumorigenesis. Inbred mouse strains vary in their susceptibility to methylcholanthrene (MCA)-initiated butylated hydroxytoluene (BHT)-promoted lung carcinogenesis. In the present study we investigated whether neutrophils play a role in strain dependent differences in susceptibility to(More)
The models to predicate software reliability using test coverage (TC) have been widely studied in recent years. An increasing number of TC based software reliability models (TC-SRMs) have been developed. Meanwhile, to quantify the degree of effectiveness of software testing comprehensively, over ten kinds of TC measures have been proposed and each of them(More)
Swarm intelligence is a relatively novel approach to problem solving that takes inspiration from the social behaviors of insects and of other animals. In particular, ants have inspired a number of methods and techniques among which the most studied and the most successful one is the ant colony optimization. Ant colony optimization (ACO) algorithm, a novel(More)
This paper provide a physically-Based framework for simulating the ground effect phenomena concerning helicopter hover between objects and the surrounding air. A simplified visual flow model including copters position and aircraft shape was introduced between the helicopter rotors and the ground. By using particle system to simulate the ground effect model,(More)
The mechanisms by which innate immune signals regulate alloimmune responses remain poorly understood. In the present study, we show by intravital 2-photon microscopy direct interactions between graft-infiltrating neutrophils and donor CD11c(+) dendritic cells (DCs) within orthotopic lung allografts immediately after reperfusion. Neutrophils isolated from(More)
The mechanisms that link bacterial infection to solid organ rejection remain unclear. In this study, we show that following the establishment of lung allograft acceptance in mice, Pseudomonas aeruginosa airway infection induces a G-CSF-dependent neutrophilia that stimulates acute rejection. Graft-infiltrating neutrophils sharply upregulate the B7 molecules(More)
Manganese-containing superoxide dismutase (Mn-SOD) is one of the most important superoxide dismutases found in many eukaryotes and bacteria. In this study, the full-length cDNA of mitochondrial manganese superoxide dismutase from Pleurotus ostreatus (PoMn-SOD) was obtained. It contained 776 nucleotides with an open reading frame (ORF) of 663 bp, encoding(More)