• Publications
  • Influence
Synthetic chalcones as potential anti-inflammatory and cancer chemopreventive agents.
TLDR
It is demonstrated that 1-3, and 7 have anti-inflammatory effects and 5, 6, and 12 are potential anti- inflammation and cancer chemopreventive agents. Expand
Antiinflammatory flavonoids from Artocarpus heterophyllus and Artocarpus communis.
TLDR
The potent inhibitory effect of compound 11 on NO production in lipopolysaccharide (LPS)-activated macrophages, probably through the suppression of iNOS protein expression, is illustrated. Expand
Structure-activity relationship studies on chalcone derivatives. the potent inhibition of chemical mediators release.
TLDR
The potent inhibitory effect of 2',5'-dihydroxy- dihydrochaclones on NO production in LPS-activated macrophages and microglial cells is proposed to be useful for the relief of septic shock. Expand
Inhibition of lipopolysaccharide-stimulated NO production by a novel synthetic compound CYL-4d in RAW 264.7 macrophages involving the blockade of MEK4/JNK/AP-1 pathway.
TLDR
The blockade of NO production by CYL-4d in LPS-stimulated RAW 264.7 cells is attributed mainly to interference in the MEK4-JNK-AP-1 signaling pathway and is not restricted to TLR4 activation and immortalized macrophage-like cells. Expand
Antiplatelet Effect and Selective Binding to Cyclooxygenase (COX) by Molecular Docking Analysis of Flavonoids and Lignans
TLDR
Flavonoids, 1, 5, 6, 7, and 8 may block the gate of the active site of COX-1 and interfere the conversion of arachidonic acid to prostaglandin (PG) H2 in the COx-1 active site. Expand
Characterization of maleimide-activated Ca2+ entry in neutrophils.
  • Jih P. Wang
  • Medicine, Chemistry
  • Biochemical pharmacology
  • 15 June 2003
TLDR
The results indicate that NEM stimulates Ca(2+) entry and regulates Ca( 2+) signaling through direct thiol oxidation, bypassing the cellular signal transduction pathway. Expand
Synthesis, anti-inflammatory, and antioxidant activities of 18beta-glycyrrhetinic acid derivatives as chemical mediators and xanthine oxidase inhibitors.
TLDR
The present results suggested 18beta-glycyrrhetic acid derivatives 2-21 were potential to be served as anti-inflammatory and antioxidant agents. Expand
Potent cytotoxic lignans from Justicia procumbens and their effects on nitric oxide and tumor necrosis factor-alpha production in mouse macrophages.
TLDR
A new lignan glycoside, 4-O-alpha-L-arabinopyranosyl-(1' "-->2' ')-beta-D-apiofuranosyldiphyllin (2), named procumbenoside A, and 11 known compounds were isolated from the whole plant of Justicia procumbens, showing potent cytotoxic effects against a number of cancer cells in vitro. Expand
Synthesis and antiinflammatory evaluation of 9-anilinoacridine and 9-phenoxyacridine derivatives.
TLDR
The results indicated that the antiinflammatory effects of acridine derivatives were mediated, at least in part, through the suppression of chemical mediators released from mast cells, neutrophils, and macrophages and that these compounds have the potential to be novel antiinflammatory agents with no significant cytotoxicity. Expand
Expression of adenylyl cyclase isoforms in neutrophils.
TLDR
Treatment of the membrane preparations from rat neutrophils with Ca(2+)/CaM, forskolin, isoproterenol, GTPgammaS or Gbetagamma all increased cyclic AMP production, and data suggest the presence of four groups of AC isoforms in rat neutophils. Expand
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