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UNLABELLED Drug-induced liver injury (DILI) is the most common cause of acute liver failure in the United-States. The aim of the study was to describe serum immune profiles associated with acute DILI, to investigate whether there are profiles associated with clinical features or types of DILI and/or with prognosis, and to assess temporal changes in levels.(More)
Receiver operating characteristic (ROC) curve is widely applied in measuring discriminatory ability of diagnostic or prognostic tests. This makes the ROC analysis one of the most active research areas in medical statistics. Many parametric and semiparametric estimation methods have been proposed for estimating the ROC curve and its functionals. In this(More)
UNLABELLED Drug-induced liver injury (DILI) is considered to be a diagnosis of exclusion. Liver biopsy may contribute to diagnostic accuracy, but the histological features of DILI and their relationship to biochemical parameters and outcomes are not well defined. We have classified the pathological pattern of liver injury and systematically evaluated(More)
The receiver operating characteristic (ROC) curve is defined as true positive rate versus false positive rate obtained by varying a decision threshold criterion. It has been widely used in medical science for its ability to measure the accuracy of diagnostic or prognostic tests. Mathematically speaking, ROC curve is the composition of survival function of(More)
Receiver operating characteristic (ROC) curve is widely applied in measuring discriminatory ability of diagnostic or prognostic tests. This makes ROC analysis one of the most active research areas in medical statistics. Many parametric and semiparametric estimation methods have been proposed for estimating the ROC curve and its functionals. In this paper,(More)
Receiver operating characteristic (ROC) curve has been widely used in medical science for its ability to measure the accuracy of diagnostic tests under the gold standard. However, in a complicated medical practice, a gold standard test can be invasive, expensive, and its result may not always be available for all the subjects under study. Thus, a gold(More)
There are various methods to estimate the parameters in the binormal model for the ROC curve. In this paper, we propose a conceptually simple and computationally accessible Bayesian estimation method using a partial likelihood based on ranks. Posterior consistency is also established. We compare the new method with other estimation methods and conclude that(More)
SUMMARY Receiver Operating Characteristic (ROC) curve has been widely used in medical science for its ability to measure the accuracy of diagnostic tests under the gold standard. However, in a complicated medical practice, a gold standard test could be invasive, expensive, and its result may not always be available for all the subjects under study. Thus a(More)
This article may be used for research, teaching and private study purposes. Any substantial or systematic reproduction, redistribution , reselling , loan or sub-licensing, systematic supply or distribution in any form to anyone is expressly forbidden. The publisher does not give any warranty express or implied or make any representation that the contents(More)