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BACKGROUND Mitochondrial DNA (mtDNA) damage may be involved in the pathogenesis of spinal and bulbar muscular atrophy (SBMA). METHODS We recruited 20 SBMA patients, 20 SBMA female carriers, and 20 normal age-matched subjects. Mitochondrial DNA damage in the 3 groups of subjects was evaluated using three novel mtDNA oxidative markers: mtDNA copy number,(More)
—Based on the analysis of several kinds of methods generally used to intercept network packets in different layers, a dynamic mechanism using NDIS intermediate drivers is proposed to protect web security, which can block malicious connection in real time. The mechanism is mainly composed of three components which include NDIS intermediate driver-based(More)
BACKGROUND Tivantinib has been described as a highly selective inhibitor of MET and is currently in a phase III clinical trial for the treatment of hepatocellular carcinoma (HCC). However, the mechanism of tivantinib anti-tumor effect has been questioned by recent studies. RESULTS We show that tivantinib indiscriminately inhibited MET dependent and(More)
Because of the limited characterization methods of the structures and morphology of N-doped carbocatalysts that are available at the atomic level, the detailed promotion mechanism of the catalytic efficiency is unspecific and the particular active sites introduced by the N atoms require further evaluation. Herein, this challenging issue is tackled by(More)
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