Jiewei Liu

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BACKGROUND Bipolar disorder is a highly heritable polygenic disorder. Recent enrichment analyses suggest that there may be true risk variants for bipolar disorder in the expression quantitative trait loci (eQTL) in the brain. AIMS We sought to assess the impact of eQTL variants on bipolar disorder risk by combining data from both bipolar disorder(More)
We exploit the power of microrheology to measure the viscoelasticity of entangled F-actin solutions at different length scales from 1 to 100 microm over a wide frequency range. We compare the behavior of single probe-particle motion to that of the correlated motion of two particles. By varying the average length of the filaments, we identify fluctuations(More)
We image semiflexible polymer networks under shear at the micrometer scale. By tracking embedded probe particles, we determine the local strain field, and directly measure its uniformity, or degree of affineness, on scales of 2-100 microm. The degree of nonaffine strain depends upon the polymer length and cross-link density, consistent with theoretical(More)
BACKGROUND Lung cancer is the leading cause of cancer-related death and has become an enormous economic burden in China. Low-dose spiral computed tomography (LDCT) screening could reduce lung cancer mortality. The feasibility of conducting a population-based lung cancer screening with LDCT in China is uncertain. METHODS In 2010, a demonstration program of(More)
Genome-wide association studies (GWASs) have identified multiple schizophrenia (SCZ) risk variants for samples of European and East Asian descent, but most of the identified susceptibility variants are population-specific to either Europeans or East Asians. This strong genetic heterogeneity suggests that differential population histories may play a role in(More)
Greatly expanded brain volume is one of the most characteristic traits that distinguish humans from other primates. Recent studies have revealed genes responsible for the dramatically enlarged human brain size (i.e., the microcephaly genes), and it has been well documented that many microcephaly genes have undergone accelerated evolution along the human(More)
Human evolution is marked by a continued enlargement of the brain. Previous studies on human brain evolution focused on identifying sequence divergences of brain size regulating genes between humans and nonhuman primates. However, the evolutionary pattern of the brain size regulating genes during recent human evolution is largely unknown. We conducted a(More)
We numerically investigate the dynamics of drop formation when a Newtonian fluid is injected through a tube into another immiscible, co-flowing Newtonian fluid with different density and viscosity using the phase field method. The two phase system is modeled by a coupled three dimensional Cahn-Hilliard and Navier-Stokes equation in cylindrical coordinates.(More)
disorder is a severe, chronic psychiatric disorder with a worldwide lifetime prevalence ranging from 0.5 to 1.5%. 1 Bipolar disorder is characterised by a variety of profound mood symptoms including episodes of mania, hypomania and depression, and is often accompanied by psychotic features and cognitive deficits. To date, there has been a fair amount of(More)
Analyses of an Asian-specific Y-chromosome lineage (O2a1-M95)--the dominant paternal lineage in Austro-Asiatic (AA) speaking populations, who are found on both sides of the Bay of Bengal--led to two competing hypothesis of this group's geographic origin and migratory routes. One hypothesis posits the origin of the AA speakers in India and an eastward(More)