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NSAID sulindac and its analog bind RXRalpha and inhibit RXRalpha-dependent AKT signaling.
Nonsteroidal anti-inflammatory drugs (NSAIDs) exert their anticancer effects through cyclooxygenase-2 (COX-2)-dependent and independent mechanisms. Here, we report that Sulindac, an NSAID, inducesExpand
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Inhibition of β-catenin Signaling by Nongenomic Action of Orphan Nuclear Receptor Nur77
Dysregulation of β-catenin turnover due to mutations of its regulatory proteins including adenomatous polyposis coli (APC) and p53 is implicated in the pathogenesis of cancer. Thus, intensive effortExpand
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Sulindac-derived RXRα modulators inhibit cancer cell growth by binding to a novel site.
Retinoid X receptor-alpha (RXRα), an intriguing and unique drug target, can serve as an intracellular target mediating the anticancer effects of certain nonsteroidal anti-inflammatory drugs (NSAIDs),Expand
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Synthesis and SAR study of modulators inhibiting tRXRα-dependent AKT activation.
RXRα represents an intriguing and unique target for pharmacologic interventions. We recently showed that Sulindac and a designed analog could bind to RXRα and modulate its biological activity,Expand
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Relative impact of 3- and 5-hydroxyl groups of cytosporone B on cancer cell viability.
A novel and the shortest route, thus far, for preparing cytosporone B (Csn-B) is reported. Csn-B and two analogs were used to probe the importance of hydroxyl groups at the 3- and 5-positions of theExpand
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Regulation of proteolytic cleavage of retinoid X receptor-α by GSK-3β.
We recently reported that an N-terminally truncated retinoid X receptor-α (tRXRα) produced in cancer cells acts to promote cancer cell growth and survival through AKT activation. However, how RXRα isExpand
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Retinoid X receptor‐α mediates (R )‐flurbiprofen’s effect on the levels of Alzheimer’s β‐amyloid
Alzheimer’s disease (AD) is characterized by the formation of extracellular senile plaques in the brain, whose major component is a small peptide called β‐amyloid (Aβ). Long‐term use of non‐steroidalExpand
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NSC-640358 acts as RXRα ligand to promote TNFα-mediated apoptosis of cancer cell
ABSTRACTRetinoid X receptor α (RXRα) and its N-terminally truncated version tRXRα play important roles in tumorigenesis, while some RXRα ligands possess potent anti-cancer activities by targeting andExpand
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Patterns of retropharyngeal lymph node metastasis in nasopharyngeal carcinoma
This study aimed to investigate the patterns of retropharyngeal lymph node (RLN) metastasis in patients with nasopharyngeal carcinoma (NPC). Sixty-two patients with NPC underwent nasopharyngealExpand
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Characteristic amino acids in tea leaves as quality indicator for evaluation of Wuyi Rock Tea in different cultured regions
Free amino acid compositions in Wuyi Rock Tea leaves from Yu (authentic rock region), Guiyan (semi-authentic rock region) and Qishan (ordinary region) tea plantations were analyzed. Results showedExpand
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