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Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15
This work identifies glial cell-derived neurotrophic factor receptor alpha-like (GFRAL) as a brainstem-restricted receptor for growth and differentiation factor 15 (GDF15), and identifies a mechanistic basis for the non-homeostatic regulation of neural circuitry by a peripheral signal associated with tissue damage and stress.
Angiotensin II activation of the JAK/STAT pathway in mesangial cells is altered by high glucose.
Evidence is provided that activation of the JAK/STAT pathway by HG or/and Ang II may be of importance in the increased GMC cell growth and collagen IV synthesis that is seen in diabetic nephropathy.
Caspase activation in retinas of diabetic and galactosemic mice and diabetic patients.
Caspases offer new therapeutic targets to test the role of apoptosis in the development of diabetic retinopathy and change with increasing duration of disease, suggesting a slowly developing caspases cascade.
Effects of p38 MAPK inhibition on early stages of diabetic retinopathy and sensory nerve function.
- Yunpeng Du, Jie-long Tang, T. Kern
- Medicine, BiologyInvestigative ophthalmology & visual science
- 1 April 2010
Inhibition of p38 MAPK offers a novel therapeutic approach to inhibiting the development of early stages of diabetic retinopathy and other complications of diabetes.
Paradoxical effects of green tea (Camellia sinensis) and antioxidant vitamins in diabetic rats: improved retinopathy and renal mitochondrial defects but deterioration of collagen matrix glycoxidation…
Green tea and antioxidant vitamins improved several diabetes-related cellular dysfunctions but worsened matrix glycoxidation in selected tissues, suggesting that antioxidant treatment tilts the balance from oxidative to carbonyl stress in the extracellular compartment.
Role of Interleukin-22 in liver diseases
- Chun-xiao Pan, Jie-long Tang, Xiao-yu Wang, Fan-rong Wu, J. Ge, Feihu Chen
- Biology, MedicineInflammation Research
- 13 March 2014
The role of IL-22 in the development progression of liver disease of different etiologies is summarized in this review, focused mainly on the IL- 22 intracellular signaling and its influence on liver diseases.
Beneficial effects of a novel RAGE inhibitor on early diabetic retinopathy and tactile allodynia
- Guangyuan Li, Jie-long Tang, Yunpeng Du, CHIEH-ALLEN Lee, T. Kern
- Medicine, BiologyMolecular vision
- 6 December 2011
Inhibition of RAGE blocked the development of important lesions of diabetic retinopathy, but these beneficial effects seemed not to be mediated via leukostasis.
CD40 in Retinal Müller Cells Induces P2X7-Dependent Cytokine Expression in Macrophages/Microglia in Diabetic Mice and Development of Early Experimental Diabetic Retinopathy
It is indicated that CD40 in Müller cells is sufficient to upregulate retinal inflammatory markers and appears to promote experimental diabetic retinopathy and that Müllers cells orchestrate inflammatory responses in myeloid cells through a CD40-ATP-P2X7 pathway.
Treatment of Lipoxin A(4) and its analogue on low-dose endotoxin induced preeclampsia in rat and possible mechanisms.
Photoreceptor Cells Influence Retinal Vascular Degeneration in Mouse Models of Retinal Degeneration and Diabetes
- Haitao Liu, Jie-long Tang, T. Kern
- Biology, MedicineInvestigative ophthalmology & visual science
- 1 August 2016
Deterioration of retinal capillaries in opsin mutants was appreciable while photoreceptor cells were present and stressed, but was less after photoreceptors degenerated, proving relevant to diabetes, where persistent stress in photoreception likewise contributes to capillary degeneration.