Learn More
miRNAs regulate gene expression by inhibiting translation or by targeting messenger RNA (mRNA) for degradation in a post-transcriptional fashion. In the present study, we show that ectopic expression of miR-34a reduces both mRNA and protein levels of cyclin D1 (CCND1) and cyclin-dependent kinase 6 (CDK6). We also demonstrate that miR-34a targets the(More)
MicroRNAs (miRNAs) are a class of small regulatory RNAs that are thought to be involved in diverse biological processes by regulating gene expression. Numerous miRNAs have been identified in various species, and many more miRNAs remain to be detected. Generally, hundreds of mRNAs have been predicted to be potential targets of one miRNA, so it is a great(More)
This paper addresses the accuracy problem of an eye gaze tracking system. We first analyze the technical barrier for a gaze tracking system to achieve desired accuracy, and then propose a subpixel tracking method to break the barrier. We present new algorithms for detecting the inner eye corner and the center of an iris in subpixel accuracy, and we apply(More)
tRNAs play a central role in protein translation, acting as the carrier of amino acids. By cloning microRNAs, we unexpectedly obtained some tRNA fragments generated by tRNA cleavage in the anticodon loop. These tRNA fragments are present in many cell lines and different mouse tissues. In addition, various stress conditions can induce this tRNA cleavage(More)
Detecting who is looking at whom during multiparty interaction is useful for various tasks such as meeting analysis. There are two contributing factors in the formation of where a person is looking at : head orientation and eye orientation. In this poster, we present an experiment aimed at evaluating the potential of head orientation estimation in detecting(More)
Natural variation in wheat requirement of long exposures to cold temperatures to accelerate flowering (vernalization) is mainly controlled by the Vrn-1, Vrn-2, Vrn-3, and Vrn-4 loci. The first three loci have been well characterized, but limited information is available for Vrn-4. So far, natural variation for Vrn-4 has been detected only in the D genome(More)
UNLABELLED MicroRNAs (miRNAs) have recently been proposed as a versatile class of molecules involved in regulation of various biological processes. Although there is emerging evidence that some microRNAs can function as oncogenes or tumor suppressors, the specific role of miRNA in human hepatocellular carcinoma (HCC) is unclear at this point. In this study,(More)
Rhinoviruses cause serious morbidity and mortality as the major etiological agents of asthma exacerbations and the common cold. A major obstacle to understanding disease pathogenesis and to the development of effective therapies has been the lack of a small-animal model for rhinovirus infection. Of the 100 known rhinovirus serotypes, 90% (the major group)(More)
In this paper we describe a method that can be used for Minimum Bayes Risk (MBR) decoding for speech recognition. Our algorithm can take as input either a single lattice, or multiple lattices for system combination. It has similar functionality to the widely used Consensus method, but has a clearer theoretical basis and appears to give better results both(More)