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Crystal structure and association behaviour of the GluR2 amino‐terminal domain
Fast excitatory neurotransmission is mediated largely by ionotropic glutamate receptors (iGluRs), tetrameric, ligand‐gated ion channel proteins comprised of three subfamilies, AMPA, kainate and NMDAExpand
A Defined Subset of Adenylyl Cyclases Is Regulated by Bicarbonate Ion*
The molecular basis by which organisms detect and respond to fluctuations in inorganic carbon is not known. The cyaB1 gene of the cyanobacterium Anabaena sp. PCC7120 codes for a multidomain proteinExpand
Botulinum neurotoxin serotype D attacks neurons via two carbohydrate-binding sites in a ganglioside-dependent manner.
The extraordinarily high toxicity of botulinum neurotoxins primarily results from their specific binding and uptake into neurons. At motor neurons, the seven BoNT (botulinum neurotoxin) serotypes A-GExpand
Molecular characterization of a novel chitinase CmChi1 from Chitinolyticbacter meiyuanensis SYBC-H1 and its use in N-acetyl-d-glucosamine production
BackgroundN-acetyl-d-glucosamine (GlcNAc) possesses many bioactivities that have been used widely in many fields. The enzymatic production of GlcNAc is eco-friendly, with high yields and a mildExpand
Improved fluorescence excitation-emission matrix regional integration to quantify spectra for fluorescent dissolved organic matter.
The purpose of this short communication is to demonstrate the importance of numerical analysis and wavelength increment selection when characterizing fluorescent dissolved organic matter (FDOM) usingExpand
The biological activity of botulinum neurotoxin type C is dependent upon novel types of ganglioside binding sites
The seven botulinum neurotoxins (BoNT) cause muscle paralysis by selectively cleaving core components of the vesicular fusion machinery. Their extraordinary activity primarily relies on highlyExpand
A Novel Class of MicroRNA Recognition Elements That Function Only in Open Reading Frames
MicroRNAs (miRNAs) are well known to target 3′ untranslated regions (3′ UTRs) in mRNAs, thereby silencing gene expression at the post-transcriptional level. Multiple reports have also indicated theExpand
Structural Basis for the Function of DCN-1 in Protein Neddylation*
Covalent modification by Nedd8 (neddylation) stimulates the ubiquitin-protein isopeptide ligase (E3) activities of Cullins. DCN-1, an evolutionarily conserved protein, promotes neddylation of CullinsExpand
Microbial co-culturing systems: butanol production from organic wastes through consolidated bioprocessing
Biobutanol can be indigenously synthesized by solventogenic Clostridium species; however, these microorganisms possess inferior capability of utilizing abundant and renewable organic wastes, such asExpand
Crystal structure of the glutamate receptor GluA1 N-terminal domain.
The AMPA (α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid) subfamily of iGluRs (ionotropic glutamate receptors) is essential for fast excitatory neurotransmission in the central nervous system.Expand