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A novel monoterpenoid indole alkaloid with anticancer activity from Melodinus khasianus.
TLDR
It was shown that khasuanine A was able to induce the apoptosis of PC3 cells by activation of caspase 3 and p53, and by inhibition of Bcl-2. Expand
Effects of St John's wort and hypericin on cytotoxicity of anticancer drugs.
TLDR
SJW extract reversed the cytotoxicity of paclitaxel and slightly of daunorubicin, down-regulated MDR1 mRNA, and inhibited MDR 1-mediated transport, presumably due to other components than hypericin. Expand
Water-compatible molecularly imprinted polymers for selective solid phase extraction of dencichine from the aqueous extract of Panax notoginseng.
TLDR
Specific molecularly imprinted polymers for dencichine were developed for the first time in this study by the bulk polymerization using phenylpyruvic acid and dl-tyrosine as multi-templates and displayed excellent hydrophilicity. Expand
Cytotoxic antibiotic angucyclines and actinomycins from the Streptomyces sp. XZHG99T
TLDR
Three new angucycline-type C-glycosides, grincamycins L–N (1–3) exhibited significant cytotoxicity against a panel of human cancer cell lines A549, H157, MCF7, MDA-MB-231, and HepG2, while 4, 8, and 9 showed decent antibacterial activity against Mycobacterium smegmatis and Staphylococcus aureus. Expand
Isolation and Purification of Three Ecdysteroids from the Stems of Diploclisia glaucescens by High-Speed Countercurrent Chromatography and Their Anti-Inflammatory Activities In Vitro
High-speed counter-current chromatography was used to separate and purify ecdysteroids for the first time from the stems of Diploclisia glaucescens using a two-phase solvent system composed of ethylExpand
[Systems biology applications to explore secondary metabolites in medicinal plants].
TLDR
It has great significance to apply this holistic and systematic method in researches on biosynthetic pathway, signal transduction, ecological environment and metabolic engineering of the formation of the secondary metabolites of medicinal plants, and in building secondary metabolite biosynthesis gene expression and regulation system model. Expand
Large-scale separation of alkaloids from Gelsemium elegans by pH-zone-refining counter-current chromatography with a new solvent system screening method.
A rapid and simple solvent system screening method was developed for pH-zone-refining counter-current chromatography (CCC) separation, which was much easier to find a suitable solvent system than theExpand
Facile synthesis of tetrahydroprotoberberine and protoberberine alkaloids from protopines and study on their antibacterial activities
TLDR
Experimental results indicated that protoberberines were the most active compounds to the target bacteria among the tested alkaloids and suggested that planar molecule with high aromatisation level or a positive charge of the molecules had a positive influence on the antibacterial effects. Expand
Synthesis of 5-methyl phenanthridium derivatives: a new class of human DOPA decarboxylase inhibitors.
TLDR
Preliminary structure-activity relationship indicated that DDC inhibitory potential of 5-methyl phenanthridium derivatives correlated with the π-electro densities on CN double bond of iminium cation. Expand
Pharmacokinetics of Active Ingredients of Salvia miltiorrhiza and Carthamus tinctorius in Compatibility in Normal and Cerebral Ischemia Rats: A Comparative Study
TLDR
The four active ingredients of S. miltiorrhiza and C. tinctorius likely integrated and interacted with each other to affect target sites in the brain to protect against cerebral ischemic injury. Expand
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