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Oesophageal cancer is one of the most aggressive cancers and is the sixth leading cause of cancer death worldwide. Approximately 70% of global oesophageal cancer cases occur in China, with oesophageal squamous cell carcinoma (ESCC) being the histopathological form in the vast majority of cases (>90%). Currently, there are limited clinical approaches for the(More)
Geographic opportunistic routing (GOR) is a new routing concept in multihop wireless networks. In stead of picking one node to forward a packet to, GOR forwards a packet to a set of candidate nodes and one node is selected dynamically as the actual forwarder based on the instantaneous wireless channel condition and node position and availability at the time(More)
OBJECTIVE The objective of this study was to compare 2-dimensional intraoral digital images with 3-dimensional cone beam CT (CBCT) in assessment of periodontal bone levels and defects. METHODS Thirty periodontal bone defects of 2 adult human skulls (with soft tissue or substitute) were evaluated by using intraoral digital radiography and CBCT. Digital(More)
Although arsenic trioxide (As(2)O(3)) induces apoptosis in a relatively wide spectrum of tumors, the sensitivity of different cell types to this treatment varies to a great extent. Because reactive oxygen species (ROS) are critically involved in As(2)O(3)-induced apoptosis, we attempted to explore the possibility that elevating the cellular ROS level might(More)
Hepatocellular carcinoma (HCC) is one of the most deadly cancers worldwide and has no effective treatment, yet the molecular basis of hepatocarcinogenesis remains largely unknown. Here we report findings from a whole-genome sequencing (WGS) study of 88 matched HCC tumor/normal pairs, 81 of which are Hepatitis B virus (HBV) positive, seeking to identify(More)
Hadoop is widely adopted to support data intensive distributed applications. Many of them are mission critical and require inherent high availability of Hadoop. Unfortunately, Hadoop has no high availability support yet, and it is not trivial to enhance Hadoop. Based on thorough investigation of Hadoop, this paper proposes a metadata replication based(More)
Fluorescent protein (FP) has enabled the analysis of biomolecular interactions in living cells, and bimolecular fluorescence complementation (BiFC) represents one of the newly developed imaging technologies to directly visualize protein-protein interactions in living cells. Although 10 different FPs that cover a broad range of spectra have been demonstrated(More)
We evaluated 190 children with very high-risk leukemia, who underwent allogeneic hematopoietic cell transplantation in 2 sequential treatment eras, to determine whether those treated with contemporary protocols had a high risk of relapse or toxic death, and whether non-HLA-identical transplantations yielded poor outcomes. For the recent cohorts, the 5-year(More)
There are currently two distinct models proposed to explain why both MDM2 and MDMX are required in p53 control, with a key difference centered on whether these two p53 inhibitors work together or independently. To test these two competing models, we generated knockin mice expressing a point mutation MDMX mutant (C462A) that is defective in MDM2 binding.(More)
Recently the research community has believed that an e-learning ecosystem is the next generation e-learning. However, the current models of e-learning ecosystems lack the support of underlying infrastructures, which can dynamically allocate the required computation and storage resources for e-learning ecosystems. Cloud computing is a promising(More)