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Cannabinoids have been consistently shown to suppress microglia activation and the release of cytotoxic factors including nitric oxide, superoxide and proinflammatory cytokines. However, the underlying molecular mechanisms and whether the action of cannabinoids is coupled to the activation of cannabinoid type 1 (CB1) and type 2 (CB2) receptors are still(More)
BACKGROUND Recent genome-wide association studies (GWASs) have reported several genetic variants to be reproducibly associated with type 2 diabetes. Additional variants have also been detected from a metaanalysis of three GWASs, performed in populations of European ancestry. In the present study, we evaluated the influence of 17 genetic variants from 15(More)
Substantial progress has been made in identification of type 2 diabetes (T2D) risk loci in the past few years, but our understanding of the genetic basis of T2D in ethnically diverse populations remains limited. We performed a genome-wide association study and a replication study in Chinese Hans comprising 8,569 T2D case subjects and 8,923 control subjects(More)
—Cyber-Individual, with a short term 'Cyber-I', is a real individual's counterpart in cyberspace. It is closely related to human-centric computing ideology which focuses on placing human in the center of computing. The study on Cyber-I tries to reexamine and analyze human essence in the digital era. Cyber-I's vision is to create a unique, digital,(More)
Polydactyly occurs in some chicken breeds, but the molecular mechanism remains incompletely understood. Combined genome-wide linkage analysis and association study (GWAS) for chicken polydactyly helps identify loci or candidate genes for the trait and potentially provides further mechanistic understanding of this phenotype in chickens and perhaps other(More)
PURPOSE Physiological fluctuations in biological tissues adversely affect MR images if present during signal acquisition. This problem is especially important for quantitative MRI. The goal of the studies reported in this study was to reduce the contributions of physiological fluctuations in quantitative MRI based on T2* tissue relaxation properties.(More)
BACKGROUND Excessive production of nitric oxide (NO) by inducible nitric oxide synthase (iNOS) in reactive microglia is a major contributor to initiation/exacerbation of inflammatory and degenerative neurological diseases. Previous studies have indicated that activation of protein kinase C (PKC) can lead to iNOS induction. Because of the existence of(More)
Accurate electricity forecasting has become a very important research field for high-efficiency electricity production. But the hybrid data-driven models for load forecasting are rarely studied. This paper presents a novel hybrid data-driven “PEK” model for predicting the daily total load. The proposed hybrid model is mainly constructed by various function(More)
OBJECTIVE We aimed to investigate whether elevated serum uric acid concentrations are associated with higher risk of metabolic syndrome (MetS) and carotid atherosclerosis in patients with type 2 diabetes. METHODS We conducted a population-based cross-sectional survey in Shanghai, with a total of 395 men and 631 women age 41 to 92 years. The carotid artery(More)