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A Molecular Grammar Governing the Driving Forces for Phase Separation of Prion-like RNA Binding Proteins
Proteins such as FUS phase separate to form liquid-like condensates that can harden into less dynamic structures. However, how these properties emerge from the collective interactions of many aminoExpand
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RNA interference targeting Fas protects mice from fulminant hepatitis
RNA interference (RNAi) is a powerful tool to silence gene expression post-transcriptionally. However, its potential to treat or prevent disease remains unproven. Fas-mediated apoptosis is implicatedExpand
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Heterotypic piRNA Ping-Pong requires qin, a protein with both E3 ligase and Tudor domains.
piRNAs guide PIWI proteins to silence transposons in animal germ cells. Reciprocal cycles of piRNA-directed RNA cleavage--catalyzed by the PIWI proteins Aubergine (Aub) and Argonaute3 (Ago3) inExpand
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Adaptation to P Element Transposon Invasion in Drosophila melanogaster
Transposons evolve rapidly and can mobilize and trigger genetic instability. Piwi-interacting RNAs (piRNAs) silence these genome pathogens, but it is unclear how the piRNA pathway adapts to invasionExpand
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Transposition-Driven Genomic Heterogeneity in the Drosophila Brain
Neuronal Transposons Transposons comprise a hefty chunk of the Drosophila genome and, unregulated, can generate mutations; thus, mechanisms exist to suppress transposon activity, particularly in theExpand
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Delivery of siRNA Therapeutics: Barriers and Carriers
RNA interference is a naturally occurring endogenous regulatory process where short double-stranded RNA causes sequence-specific posttranscriptional gene silencing. Small interference RNA (siRNA)Expand
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The HP1 Homolog Rhino Anchors a Nuclear Complex that Suppresses piRNA Precursor Splicing
piRNAs guide an adaptive genome defense system that silences transposons during germline development. The Drosophila HP1 homolog Rhino is required for germline piRNA production. We show that RhinoExpand
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Reproducible copy number variation patterns among single circulating tumor cells of lung cancer patients
  • X. Ni, M. Zhuo, +22 authors Jie Wang
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 9 December 2013
Significance In a few milliliters of blood from a cancer patient, one can isolate a few circulating tumor cells (CTCs). Originating from the primary tumor, CTCs seed metastases, which account for theExpand
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UAP56 Couples piRNA Clusters to the Perinuclear Transposon Silencing Machinery
piRNAs silence transposons during germline development. In Drosophila, transcripts from heterochromatic clusters are processed into primary piRNAs in the perinuclear nuage. The nuclear DEAD boxExpand
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Ehd4 Encodes a Novel and Oryza-Genus-Specific Regulator of Photoperiodic Flowering in Rice
Land plants have evolved increasingly complex regulatory modes of their flowering time (or heading date in crops). Rice (Oryza sativa L.) is a short-day plant that flowers more rapidly in short-dayExpand
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