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Sequence census methods like ChIP-seq now produce an unprecedented amount of genome-anchored data. We have developed an integrative method to identify patterns from multiple experiments simultaneously while taking full advantage of high-resolution data, discovering joint patterns across different assay types. We apply this method to ENCODE chromatin data(More)
In recent years, convolutional neural network (CNN) based methods have achieved great success in a large number of applications and have been among the most powerful and widely used techniques in computer vision. However, CNN-based methods are com-putational-intensive and resource-consuming, and thus are hard to be integrated into embedded systems such as(More)
Birds are the most species-rich class of tetrapod vertebrates and have wide relevance across many research fields. We explored bird macroevolution using full genomes from 48 avian species representing all major extant clades. The avian genome is principally characterized by its constrained size, which predominantly arose because of lineage-specific erosion(More)
BACKGROUND Recent advance in genetic studies added the confirmed susceptible loci for type 2 diabetes to eighteen. In this study, we attempt to analyze the independent and joint effect of variants from these loci on type 2 diabetes and clinical phenotypes related to glucose metabolism. METHODS/PRINCIPAL FINDINGS Twenty-one single nucleotide polymorphisms(More)
Human carboxylesterase (CES) 1 and CES2 are members of the serine hydrolase superfamily, and both exhibit broad substrate specificity and are involved in xenobiotic and endobiotic metabolism. Although expression of CES1 and CES2 occurs in several organs, their expression in liver and small intestine is predominantly attributed to CES1 and CES2,(More)
Lasso is a widely used regression technique to find sparse representations. When the dimension of the feature space and the number of samples are extremely large, solving the Lasso problem remains challenging. To improve the efficiency of solving large-scale Lasso problems, El Ghaoui and his colleagues have proposed the SAFE rules which are able to quickly(More)
VCells, the proposed Edge-Weighted Centroidal Voronoi Tessellations (EWCVTs)-based algorithm, is used to generate superpixels, i.e., an oversegmentation of an image. For a wide range of images, the new algorithm is capable of generating roughly uniform subregions and nicely preserving local image boundaries. The undersegmentation error is effectively(More)
This paper deals with data (or information) fusion for the purpose of estimation. Three estimation fusion architectures are considered: centralized, distributed, and hybrid. A unified linear model and a general framework for these three architectures are established. Optimal fusion rules based on the best linear unbiased estimation (BLUE), the weighted(More)
Land plants have evolved increasingly complex regulatory modes of their flowering time (or heading date in crops). Rice (Oryza sativa L.) is a short-day plant that flowers more rapidly in short-day but delays under long-day conditions. Previous studies have shown that the CO-FT module initially identified in long-day plants (Arabidopsis) is evolutionary(More)
With the development of emerging social networks, such as Facebook and MySpace, security and privacy threats arising from social network analysis bring a risk of disclosure of confidential knowledge when the social network data is shared or made public. In addition to the current social network anonymity de-identification techniques, we study a situation,(More)