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The CYP2F1 gene encodes a cytochrome P450 enzyme capable of bioactivating a number of pulmonary-selective toxicants. The expression of CYP2F1 is highly tissue-selective; the highest expression is observed in the lung with little or no hepatic expression. The objective of these studies was to elucidate the mechanisms that govern the unique tissue-specific(More)
This article illustrates the general problem known as ‘simulation optimization’ through an (s,S) inventory management system. In this system, the goal function to be minimized is the expected value of specific inventory costs. Moreover, specific constraints must be satisfied for some random simulation responses, namely the service or fill rate, and for some(More)
In this study, an automated adaptive mesh control scheme, based on local mesh modifications, is developed for the finite element simulations of 3D metal forming processes. Error indicators are used to control the mesh discretization errors, and a consecutive h-adaptive procedure is conducted. The mesh size field used in the h-adaptive procedure is processed(More)
We previously reported that acetaminophen (APAP, 4-hydroxyacetanilide) caused apoptosis of C6 glioma cells. Therefore, we hypothesized that the level of p53, which usually stimulates apoptosis, might be increased after APAP exposure. However, APAP exposure for 24 h markedly decreased the p53 content and its downstream target p21 in a concentration-dependent(More)
Activity recognition is fundamental to many of the services envisaged in pervasive computing and ambient intelligence scenarios. However, delivering sufficiently robust activity recognition systems that could be deployed with confidence in an arbitrary real-world setting remains an outstanding challenge. Developments in wireless, inexpensive and unobtrusive(More)
Two vital enzymes of the CYP3A subfamily, CYP3A4 and CYP3A5, are differentially expressed in the human lung. However, the molecular mechanisms that regulate tissue-selective expression of the genes are poorly understood. The ability of the 5' upstream promoter region of these two genes to drive luciferase reporter activities in human lung A549 cells was(More)
1ABSTRACT – Midwest ISO’s real-time market design with energy and ancillary service co-optimization is reported in this paper. The key components of Midwest ISO’s real-time market are described including intra-day reliability commitment, transmission security management, real-time dispatch and pricing. The RT SCED formulation at the core of the real-time(More)
High-quality Mn:ZnS doped nanocrystals (d-dots) with photoluminescence (PL) quantum yield (QY) of 50-70% have been synthesized based on nucleation-doping strategy by choosing 1-dodecanethiol (DDT) as the capping ligand. Controlling the growth of small-sized MnS core nanoclusters was successfully achieved by changing the injection temperature of sulfur(More)
BACKGROUND The relationship between overweight or obesity and mortality in peritoneal dialysis (PD) patients remains controversial. Both pulse-wave velocity (PWV) and endothelial dysfunction are related to an increased risk of cardiovascular disease. However, the association between PWV, endothelial dysfunction, and visceral adipose tissue in PD patients is(More)