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The CYP2F1 gene encodes a cytochrome P450 enzyme capable of bioactivating a number of pulmonary-selective toxicants. The expression of CYP2F1 is highly tissue-selective; the highest expression is observed in the lung with little or no hepatic expression. The objective of these studies was to elucidate the mechanisms that govern the unique tissue-specific(More)
Earlier data showed that men fasted for 38 h had a reduced rate of chlorzoxazone metabolism, suggesting a decreased level of cytochrome P450 2E1 (CYP2E1). In contrast, the level of CYP2E1 in fasted rats had been shown to be elevated. In this study, we have investigated whether chlorzoxazone metabolism in fasted rats was changed by determining the(More)
11 This article illustrates the general problem known as 'simulation optimization' through an (s, S) inventory management sys-12 tem. In this system, the goal function to be minimized is the expected value of specific inventory costs. Moreover, specific con-13 straints must be satisfied for some random simulation responses, namely the service or fill rate,(More)
Activity recognition is fundamental to many of the services envisaged in pervasive computing and ambient intelligence scenarios. However, delivering sufficiently robust activity recognition systems that could be deployed with confidence in an arbitrary real-world setting remains an outstanding challenge. Developments in wireless, inexpensive and unobtrusive(More)
Increased nitroxidative stress causes mitochondrial dysfunctions through oxidative modifications of mitochondrial DNA, lipids, and proteins. Persistent mitochondrial dysfunction sensitizes the target cells/organs to other pathological risk factors and thus ultimately contributes to the development of more severe disease states in alcoholic and nonalcoholic(More)
High-quality Mn:ZnS doped nanocrystals (d-dots) with photoluminescence (PL) quantum yield (QY) of 50-70% have been synthesized based on nucleation-doping strategy by choosing 1-dodecanethiol (DDT) as the capping ligand. Controlling the growth of small-sized MnS core nanoclusters was successfully achieved by changing the injection temperature of sulfur(More)
Selective transcription of the human CYP2F1 gene in lung tissues may control the susceptibilities of this organ to diverse pneumotoxicants and lung carcinogens. However, the mechanisms responsible for CYP2F1 organ-selective transcription have not been elucidated. The objectives of the current studies were to identify and characterize basal transcription(More)
Ambient Assisted Living (AAL) is of particular relevance to those who may suffer from Alzheimer's Disease or dementia, and, of course, their carers. The slow but progressive nature of the disease, together with its neurological nature, ultimately compromises the behavior and function of people who may be essentially healthy from a physical perspective. An(More)
Large doses of acetaminophen (APAP) could cause oxidative stress and tissue damage through production of reactive oxygen/nitrogen (ROS/RNS) species and quinone metabolites of APAP. Although ROS/RNS are known to modify DNA, the effect of APAP on DNA modifications has not been studied systematically. In this study, we investigate whether large doses of APAP(More)