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Reactive oxygen species-mediated mitochondrial pathway is involved in Baohuoside I-induced apoptosis in human non-small cell lung cancer.
Baohuoside I (also known as Icariside II) is a flavonoid isolated from Epimedium koreanum Nakai. Although Baohuoside I exhibits anti-inflammatory and anti-cancer activities, its molecular… Expand
Formulation and Evaluation of Celastrol-Loaded Liposomes
The main purpose of this study was to evaluate the intestinal absorption and the antineoplastic effect of the poorly water-soluble drug celastrol when liposomes were used as oral drug delivery… Expand
Enhanced bioavailability of apigenin via preparation of a carbon nanopowder solid dispersion
- Shu-min Ding, Zhen-hai Zhang, Jie Song, Xu-dong Cheng, J. Jiang, Xiao-Bin Jia
- Materials Science, Medicine
- International journal of nanomedicine
- 13 May 2014
In this study, a novel carbon nanopowder (CNP) drug carrier was developed to improve the oral bioavailability of apigenin (AP). Solid dispersions (SDs) of AP with CNP were prepared, and their in… Expand
Apoptosis induction by alantolactone in breast cancer MDA-MB-231 cells through reactive oxygen species-mediated mitochondrion-dependent pathway
- L. Cui, Wei-quan Bu, +15 authors X. Jia
- Chemistry, Medicine
- Archives of pharmacal research
- 1 March 2018
Alantolactone is a sesquiterpene lactone isolated from Inula helenium L. Although alantolactone possesses anti-inflammation and apoptosis-induction activities, the underlying mechanism of anti-cancer… Expand
A nanostructured liquid crystalline formulation of 20(S)-protopanaxadiol with improved oral absorption.
As with many other anti-cancer agents, 20(S)-protopanaxadiol (PPD) has a low oral absorption. In this study, in order to improve the oral bioavailability of PPD, the cubic nanoparticles that it… Expand
Protection of glycyrrhizic acid against AGEs-induced endothelial dysfunction through inhibiting RAGE/NF-κB pathway activation in human umbilical vein endothelial cells.
ETHNOPHARMACOLOGICAL RELEVANCE Licorice (Glycyrrhiza uralensis roots) is used as a traditional medicine for the treatment of diabetes mellitus and its vascular complications. Glycyrrhizic acid (GA,… Expand
Icariside II inhibits the EMT of NSCLC cells in inflammatory microenvironment via down‐regulation of Akt/NF‐κB signaling pathway
- Jie Song, Liang Feng, +6 authors Zhen-hai Zhang
- Biology, Medicine
- Molecular carcinogenesis
- 1 January 2017
Inflammatory microenvironment created by immune cells is favorable for tumor metastasis. Epithelial‐mesenchymal transition (EMT) is involved in the progression of cancer invasion and metastasis in… Expand
Protective Effect of Standardized Extract of Ginkgo biloba against Cisplatin-Induced Nephrotoxicity
- Jie Song, Dan Liu, Liang Feng, Zhen-hai Zhang, X. Jia, Wei Xiao
- Evidence-based complementary and alternative…
- 25 November 2013
Cisplatin (CDDP) is a potent antitumor compound widely used with a notably side effect of nephrotoxicity inducing oxidative stress and apoptosis in kidneys. Standardized extract from the leaves of… Expand
Crude terpene glycoside component from Radix paeoniae rubra protects against isoproterenol-induced myocardial ischemic injury via activation of the PI3K/AKT/mTOR signaling pathway.
ETHNOPHARMACOLOGICAL RELEVANCE Radix paeoniae rubra, also known as chishao (CS), is a frequently used traditional Chinese medicine that can promote blood circulation to remove blood stasis. It has… Expand
Beneficial Effects of a Flavonoid Fraction of Herba Epimedii on Bone Metabolism in Ovariectomized Rats.
A flavonoid fraction of Herba Epimedii, including eight flavonoid glycoside compounds, epimedoside A, ikarisoside F, baohuoside II, sagittatoside A, sagittatoside B, 7-O-rhamnosyl icariside II,… Expand