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  • Jie Jack Li, Joe Nahra, +9 authors Hyo-Kyung Han
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 2008 (First Publication: 1 February 2008)
  • Quinazolinones 8 and pyrido[3,4-d]pyrimidin-4-ones 9 as orally active and specific matrix metalloproteinase-13 inhibitors were discovered for the treatment of osteoarthritis. Starting from aContinue Reading
  • Jie Jack Li, Kenneth G. Carson, +12 authors Stephen Hunt
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry
  • 2003 (First Publication: 1 August 2003)
  • Interleukin-8 modulation is implicated in many inflammatory and cancer diseases. Starting from a mass-screening hit, the synthesis and structure-activity relationship ofContinue Reading