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Synthetic aperture radar (SAR) image classification is a hot topic in the interpretation of SAR images. However, the absence of effective feature representation and the presence of speckle noise in SAR images make classification difficult to handle. In order to overcome these problems, a deep convolutional autoencoder (DCAE) is proposed to extract features(More)
Hox genes are known to play a key role in shaping the body plan of metazoans. Evolutionary dynamics of these genes is therefore essential in explaining patterns of evolutionary diversity. Among extant sarcopterygians comprising both lobe-finned fishes and tetrapods, our knowledge of the Hox genes and clusters has largely been restricted in several model(More)
Piezo proteins have been proposed as the long-sought-after mechanosensitive cation channels in mammals that play critical roles in various mechanotransduction processes. However, the molecular bases that underlie their ion permeation and mechanotransduction have remained functionally undefined. Here we report our finding of the miniature pore-forming module(More)
PDE4 (phosphodiesterase-4)-selective inhibitors have attracted much attention as potential therapeutics for the treatment of both depression and major inflammatory diseases, but their practical application has been compromised by side effects. A possible cause for the side effects is that current PDE4-selective inhibitors similarly inhibit isoforms from all(More)
Human leishmaniasis is a major public health problem in many countries, but chemotherapy is in an unsatisfactory state. Leishmania major phosphodiesterases (LmjPDEs) have been shown to play important roles in cell proliferation and apoptosis of the parasite. Thus LmjPDE inhibitors may potentially represent a novel class of drugs for the treatment of(More)
BACKGROUND MicroRNAs (miRNAs) are widely involved in the process of chronic heart failure (HF), which is characterized by reactivation of the fetal gene program. Here, we examined whether the serum expression levels of some HF-related miRNAs in adult HF patients would tend to revert to fetal levels. METHODS AND RESULTS Serum was obtained from the(More)
Deep learning, which represents data by a hierarchical network, has proven to be efficient in computer vision. To investigate the effect of deep features in hyperspectral image (HSI) classification, this paper focuses on how to extract and utilize deep features in HSI classification framework. First, in order to extract spectral-spatial information, an(More)
The hysteresis nonlinear characteristic of the nanometer positioning system based on piezoceramic actuator decreases the accuracy of the nanometer positioning stage seriously. To compensate the hysteresis nonlinearity and improve the precision of system with hysteresis, the modeling of hysteresis and the corresponding inverse compensation is studied in this(More)