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Origin and evolution of pathogenic coronaviruses
The viral factors that enabled the emergence of diseases such as severe acute respiratory syndrome and Middle East respiratory syndrome are explored and the diversity and potential of bat-borne coronaviruses are highlighted.
On the origin and continuing evolution of SARS-CoV-2
The results suggest that the development of new variations in functional sites in the receptor-binding domain (RBD) of the spike seen in SARS-CoV-2 and viruses from pangolin SARSr-CoVs are likely caused by natural selection besides recombination.
Comparative genomics reveals insights into avian genome evolution and adaptation
This work explored bird macroevolution using full genomes from 48 avian species representing all major extant clades to reveal that pan-avian genomic diversity covaries with adaptations to different lifestyles and convergent evolution of traits.
Discovery of a rich gene pool of bat SARS-related coronaviruses provides new insights into the origin of SARS coronavirus
It is hypothesized that the direct progenitor of SARS-CoV may have originated after sequential recombination events between the precursors of these SARSr-CoVs, and highlights the necessity of preparedness for future emergence of Sars-like diseases.
Contraction of the type I IFN locus and unusual constitutive expression of IFN-α in bats
It is demonstrated that bat IFN-α genes are constitutively expressed in unstimulated bat tissues and cells and their expression is unaffected by viral infection, providing evidence for a unique IFN system that may be linked to the ability of bats to coexist with viruses.
Dampened STING-Dependent Interferon Activation in Bats
Identification of diverse groups of endogenous gammaretroviruses in mega- and microbats.
The discovery of RNA transcripts from two putative endogenous gammaretroviruses in frugivorous and insectivorous bat species indicates that bats harbour distinct gammeretrovirus and may have played an important role as reservoir hosts during the diversification of mammalian gammarenrovirus.
Zika virus infection induces RNAi-mediated antiviral immunity in human neural progenitors and brain organoids
It is shown that ZIKV infection triggers the abundant production of virus-derived small interfering RNAs in hNPCs, but not in the more differentiated progenies or somatic cells, and enoxacin, a broad-spectrum antibiotic that is known as an RNAi enhancer, exerts potent anti-ZIKV activity in hnPCs and other RNAi-competent cells.
Bat origin of a new human coronavirus: there and back again
A novel coronavirus reported to cause pneumonia in 41 people during December 2019 in Wuhan, the capital of Hubei province, China, was identified and designated as the 2019-nCoV, a single-stranded, positive-sense RNA genome, but genetically distinct from SARS- coV and Middle East respiratory syndrome coronav virus (MERS-CoV.