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Therapeutic applications of microRNA (miRNA) in KRAS-driven pancreatic cancers might be valuable, but few studies have explored this area. Here, we report that miR-96 directly targets the KRAS oncogene and functions as a tumor-suppressing miRNA in pancreatic cancer cells. Ectopic expression of miR-96 through a synthetic miRNA precursor inhibited KRAS,(More)
This paper is concerned with the problem of stability and stabilization of neutral time-delay systems. A new delay-dependent stability condition is derived in terms of linear matrix inequality by constructing a new Lyapunov functional and using some integral inequalities without introducing any free-weighting matrices. On the basis of the obtained stability(More)
Aberrantly expressed microRNA (miRNA) is frequently associated with a variety of cancers, including pancreatic ductal adenocarcinoma (PDAC). In this study, we investigated the expression and possible role of miR-217 in PDAC. Data obtained by locked nucleic acid in situ hybridization and real-time quantitative polymerase chain reaction showed that miR-217(More)
This paper presents a simple adaptation mechanism to automatically adjust the ratio of foragers to resters (division of labour) in a swarm of foraging robots and hence maximise the net energy income to the swarm. Three adaptation rules are introduced based on local sensing and communications. Individual robots use internal cues (successful food retrieval),(More)
To estimate the distribution of lymphoid neoplasms in China, we conducted a comprehensive analysis, based on subtype, age, sex, and lesion, of primary and resected biopsy specimens of 4,638 lymphoid neoplasms diagnosed from 2004 to 2008 at 5 large hospitals. Of the 4,638 patients, mature B-cell neoplasms accounted for 64.3% of all lymphoid neoplasms, mature(More)
This article presents a simple adaptation mechanism to automatically adjust the ratio of foragers to resters (division of labor) in a swarm of foraging robots and hence maximize the net energy income to the swarm. Three adaptation rules are introduced based on local sensing and communications. Individual robots use internal cues (successful food retrieval),(More)