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A community computational challenge to predict the activity of pairs of compounds
Recent therapeutic successes have renewed interest in drug combinations, but experimental screening approaches are costly and often identify only small numbers of synergistic combinations. The DREAMExpand
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  • Open Access
Transcriptional interference by antisense RNA is required for circadian clock function
Eukaryotic circadian oscillators consist of negative feedback loops that generate endogenous rhythmicities. Natural antisense RNAs are found in a wide range of eukaryotic organisms. Nevertheless, theExpand
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Prediction of human population responses to toxic compounds by a collaborative competition
The ability to computationally predict the effects of toxic compounds on humans could help address the deficiencies of current chemical safety testing. Here, we report the results from aExpand
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  • Open Access
Glutathione S-transferase Mu 2-transduced mesenchymal stem cells ameliorated anti-glomerular basement membrane antibody-induced glomerulonephritis by inhibiting oxidation and inflammation
  • Y. Li, Mei Yan, +6 authors Q. Li
  • Biology, Medicine
  • Stem Cell Research & Therapy
  • 30 January 2014
IntroductionOxidative stress is implicated in tissue inflammation, and plays an important role in the pathogenesis of immune-mediated nephritis. Using the anti-glomerular basement membraneExpand
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Influence of Carbon Monoxide on Growth and Apoptosis of Human Umbilical Artery Smooth Muscle Cells and Vein Endothelial Cells
Carbon monoxide (CO) is a vasoactive molecule that is generated by vascular cells as a byproduct of heme catabolism and it plays an important physiological role in circulation system. In order toExpand
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  • Open Access
Kallikrein Transduced Mesenchymal Stem Cells Protect against Anti-GBM Disease and Lupus Nephritis by Ameliorating Inflammation and Oxidative Stress
Previously we have shown that kallikreins (klks) play a renoprotective role in nephrotoxic serum induced nephritis. In this study, we have used mesenchymal stem cells (MSCs) as vehicles to deliverExpand
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  • Open Access
I4U Submission to NIST SRE 2018: Leveraging from a Decade of Shared Experiences
tl;dr
The I4U consortium was established to facilitate a joint entry to NIST speaker recognition evaluations (SRE). Expand
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  • Open Access
Detection of candidate tumor driver genes using a fully integrated Bayesian approach.
DNA copy number alterations (CNAs), including amplifications and deletions, can result in significant changes in gene expression and are closely related to the development and progression of manyExpand
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  • Open Access
CBC-Based Synthetic Speech Detection
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Meta-analysis of segmentectomy versus lobectomy for radiologically pure solid or solid-dominant stage IA non-small cell lung cancer
ObjectiveWhether segmentectomy can be used to treat radiologically determined pure solid or solid-dominant lung cancer remains controversial owing to the invasive pathologic characteristics of theseExpand
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