Jiazuo H. Feng

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We aimed to determine whether the myocardial extracellular volume (ECV), measured using T1 measurements obtained during cardiac magnetic resonance imaging were increased in patients treated with anthracyclines. We performed cardiac magnetic resonance imaging and echocardiography and measured the ECV in 42 patients treated with anthracyclines. The data from(More)
Effect of purified omega-3 fatty acids on reducing left ventricular remodeling after acute myocardial infarction (OMEGA-REMODEL study): a double-blind randomized clinical trial) Bobby Heydari, Siddique A Abbasi, Ravi Shah, Shuaib Abdullah, Jiazuo Feng, William Harris, Joe McConnell, Evan Appelbaum, Udo Hoffmann, Michael Steigner, Ron Blankstein, Elliott A(More)
In pancreatic β-cells, liver hepatocytes, and cardiomyocytes, chronic exposure to high levels of fatty acids (lipotoxicity) inhibits autophagic flux and concomitantly decreases lysosomal acidity. Whether impaired lysosomal acidification is causally inhibiting autophagic flux and cellular functions could not, up to the present, be determined because of the(More)
Background Changes in left ventricular compliance caused by diffuse fibrosis after MI may result in diastolic dysfunction and left atrial enlargement. We sought to test the hypothesis that left atrial volume is associated with ECV (a marker of diffuse myocardial fibrosis) during the sub-acute phase of infarction and can predict the increase of ECV during(More)
Background Aortic valve replacement (AVR) is the definitive treatment for severe symptomatic aortic stenosis (AS). Aortic stenosis is associated with diastolic dysfunction and left atrial (LA) enlargement. After a successful AVR, there is a decrease in LA size but persistence in diatolic dysfunction. We hypothesized that LA function would help link this(More)
CMR quantification of infarct tissue heterogeneity and remote myocardial fibrotic burden during convalescent phase following acute myocardial infarction (MI) provided strong and complementary evidence of ventricular arrhythmogenicity from quantitative microvolt T-wave alternans testing (the NHLBI PROSPECT-CMR study) Bobby Heydari, Shuaib Abdullah, Evan(More)
Background Myocardial tagging is considered a gold-standard technique to derive myocardial strain using cardiac magnetic resonance (CMR) in large epidemiologic studies. Nevertheless technical limitations related to tag line fading (via T1 relaxation) limit generalizability and reproducibility of this technique. Our purpose was to test myocardial tagging(More)
ST2 is reduced by high-dose omega-3 fatty acid treatment following acute MI and is correlated with reduction of the extracellular volume fraction of non-infarcted myocardium Bobby Heydari, Shuaib Abdullah, James V Pottala, Ravi V Shah, Siddique A Abbasi, Damien Mandry, Heidi Lumish, Udo Hoffmann, Evan Appelbaum, Jiazuo Feng, Ron Blankstein, Michael(More)
Background A recent large-scale clinical trial has indicated that an initial invasive strategy does not improve cardiac outcomes beyond optimized medical therapy in patients with stable coronary artery disease (CAD). Therefore, novel methods to stratify at-risk patients may refine therapeutic decisions and improve outcomes. We sought to test the hypothesis(More)
Characterization of subacute and convalescent fibrotic burden in the remote myocardium after acute infarction provides strong and incremental prediction of changes in left and right functions and final infarct size, incremental to knowledge of the subacute infarct size Damien Mandry, Evan Appelbaum, Bobby Heydari, Shuaib Abdullah, Sanjeev Francis, Heidi S(More)