Jiayu Fu

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OBJECTIVE To investigate the mechanism of STI571 inducing apoptosis of K562 cells which express P210(BCR/ABL). METHODS Apoptosis was analyzed by Annexin-V/PI, DioC6 [3] staining, DCFH-DA staining, DNA-PI staining and DNA ladder. Western blot was used to analyse mitochondrial and cytosolic cyto C, Bcl-X(L), caspase-3, actin protein and the level of(More)
OBJECTIVES The aim of this study was to investigate the prevalence of temporomandibular disorders (TMD) symptoms and their association with sleep quality and psychological distress in Chinese adolescents. METHODS Five hundred seventy-eight adolescents were enrolled in the study and completed a self-reported TMD symptom questionnaire and socio-demographics(More)
OBJECTIVE To investigate the effect of antisense vascular endothelial growth factor (VEGF)(121) cDNA transfection on the growth of K562 cells in nude mice. METHODS K562 cells transfected with the antisense (AS) or sense (S) VEGF(121) cDNA, and the vector (V, pcDNA3) alone were transplanted subcutaneously into nude mice and the growth of the transfected(More)
According to our previous experiments, Ph(+) chronic myeloid leukemia (CML) cell line K562 cells have defects in beta 1 integrin activation. In order to search the same regularity in Ph(+) CML bone marrow cells, bone marrow mononuclear cells (BMMNC) from 12 cases of Ph(+) CML and 10 cases of normal individuals were studied. Their expression rate of 9EG7(More)
The purpose of this study was to investigate the function of dendritic cells derived from chronic myeloid leukemia (CML-DC). Mononuclear cells were prepared from bone marrow and peripheral blood of 24 patients with CML, and the DCs were obtained by incubation of MNCs with media containing GM-CSF, IL-4 and TNF-alpha. The phenotype of CML-DCs was identified(More)
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