Jiayi Wu

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The NLR family apoptosis inhibitory proteins (NAIPs) bind conserved bacterial ligands, such as the bacterial rod protein PrgJ, and recruit NLR family CARD-containing protein 4 (NLRC4) as the inflammasome adapter to activate innate immunity. We found that the PrgJ-NAIP2-NLRC4 inflammasome is assembled into multisubunit disk-like structures through a(More)
Melanoma is the most lethal form of skin cancer, but recent advances in molecularly targeted agents against the Ras/Raf/MAPK pathway demonstrate promise as effective therapies. Despite these advances, resistance remains an issue, as illustrated recently by the clinical experience with vemurafenib. Such acquired resistance appears to be the result of(More)
Estrogen receptor (ER), progesterone receptor (PgR), HER2, and Ki67 have been increasingly evaluated by core needle biopsy (CNB) and are recommended for classifying breast cancer into molecular subtypes. However, the concordance rate between CNB and open excision biopsy (OEB) has not been well documented. Patients with paired CNB and OEB samples from Oct.(More)
PURPOSE Few studies has documented early relapse in luminal B/HER2-negative breast cancer. We examined prognostic factors for early relapse among these patients to improve treatment decision-making. PATIENTS AND METHODS A total 398 patients with luminal B/HER2-negative breast cancer were included. Kaplan-Meier curves were applied to estimate disease-free(More)
Triple negative breast cancer (TNBC) occurs in approximately 10% to 25% of all patients with breast cancer and is associated with poor prognosis. Neo-adjuvant chemotherapy has been reported to produce a higher pathologic complete response (pCR) rate in TNBC. If pCR is achieved, patients with TNBC had a similar survival with non-TNBC patients. The aim of our(More)
Message-oriented middleware (MOM) provides a messaging service layer between the transport and application layer of the networking protocol stack. A resilient and QoS-aware MOM system provides dependable QoS, and strives to maintain and recover a required level of messaging in the face of challenges, e.g., bursty surges in workload demand and failures in(More)
This paper examines the issues of traffic load balancing in wideband code division multiple access (WCDMA) mobile communication networks through applying dynamic radio coverage. Dynamic radio coverage is achieved by adjusting radiation patterns of antenna arrays and the optimization of coverage is carried out cooperatively between cells using dedicatedly(More)
BACKGROUND This study is a retrospective evaluation of the efficacy of neoadjuvant chemotherapy (NC) with a vinorelbine (V) and epirubicin (E) intravenous combination regimen and is aimed at identification of predictive markers for the long-term outcome in noninflammatory locally advanced breast cancer (NLABC). METHODS One-hundred-and-nineteen patients(More)
The generalized ESPRIT (GESPRIT) method extends the conventional ESPRIT estimator to estimate the directions-of-arrival (DOAs) of multiple incident signals by using the array with more general geometrical configurations, where the translational invariance structure is not required. Unfortunately, the GESPRIT has serious ambiguous DOA estimates in some(More)