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Tubulin, the subunit protein of microtubules, is an α/β heterodimer. Both α- and β-tubulin exist as numerous isotypes, differing in their amino acid sequences and encoded by different genes. The differences are highly conserved in evolution, suggesting that they are functionally significant. Neurons are a potentially very useful system for elucidating this(More)
It has been demonstrated that cyclooxygenase-2 (COX-2) is expressed in melanoma tissues and prosta-glandin E 2 (PGE 2) is produced by melanoma cells in vitro. However, the roles of COX-2/PGE 2 in melanoma are largely unknown. In the present study, we set out to analyze the correlation of endogenous PGE 2 with the expression of macrophage chemoattractant(More)
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