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Central role for Rho in TGF-beta1-induced alpha-smooth muscle actin expression during epithelial-mesenchymal transition.
TLDR
Rho plays a dual role in TGF-beta(1)-induced EMT of renal epithelial cells, indispensable both for cytoskeleton remodeling and for the activation of the SMA promoter.
Central role for Rho in TGF-β1-induced α-smooth muscle actin expression during epithelial-mesenchymal transition
New research suggests that, during tubulointerstitial fibrosis, α-smooth muscle actin (SMA)-expressing mesenchymal cells might derive from the tubular epithelium via epithelial-mesenchymal transiti...
Melatonin receptor mRNA expression in human granulosa cells
TLDR
The expression of mt1 and MT2 receptor mRNA in HG cells and the reported presence of melatonin in human follicular fluid indicate a potentially important role for this hormone in regulating human ovarian and reproductive function.
Transcriptional Regulation of a Contractile Gene by Mechanical Forces Applied through Integrins in Osteoblasts*
TLDR
It is concluded that the CArG-B box is a force-responsive element in the SMA promoter, which regulates mechanotranscriptional regulation of the contractile gene, α-smooth muscle actin, in osteoblastic cells.
Plasmodium falciparum: development of a transgenic line for screening antimalarials using firefly luciferase as the reporter.
TLDR
A simple, robust, and cell-based luminescent method for assaying antimalarial drugs and is robust with a Z' score of 0.77-0.92, which suggests the feasibility for further miniaturization and automation.
Multiple roles of α-smooth muscle actin in mechanotransduction
TLDR
In addition to its importance as a structural protein in tissue remodeling and contraction, SMA may serve as a mechanotransducer, based on its ability to physically link mechanosensory elements and to enhance its own, force-induced expression.
Regulation of L‐Threonine Dehydrogenase in Somatic Cell Reprogramming
TLDR
It is suggested that TDH‐mediated threonine catabolism controls somatic cell reprogramming and the importance of post‐transcriptional and post-translational regulation of TDH is indicated.
Jab1 is a target of EGFR signaling in ERα-negative breast cancer
TLDR
Jab1 is a target of EGFR signaling in ER α- cell lines and breast tumors and therefore may be a common central factor and potential therapeutic target for important cell signaling pathways in ERα- breast cancer.
A systematic benchmark of Nanopore long read RNA sequencing for transcript level analysis in human cell lines
TLDR
Increased read length improves read-to-transcript assignment, identifies interactions between alternative promoters and splicing, enables the discovery of novel transcripts from repetitive regions, facilitates the quantification of full-length fusion isoforms and enables the simultaneous profiling of m6A RNA modifications when RNA is sequenced directly.
Multiple roles of alpha-smooth muscle actin in mechanotransduction.
TLDR
In addition to its importance as a structural protein in tissue remodeling and contraction, SMA may serve as a mechanotransducer, based on its ability to physically link mechanosensory elements and to enhance its own, force-induced expression.
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