Jiaxing Cheng

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Protein-protein interactions (PPIs) play key roles in most cellular processes, such as cell metabolism, immune response, endocrine function, DNA replication, and transcription regulation. PPI prediction is one of the most challenging problems in functional genomics. Although PPI data have been increasing because of the development of high-throughput(More)
Identification of protein-protein interface residues is crucial for structural biology. This paper proposes a covering algorithm for predicting protein-protein interface residues with features including protein sequence profile and residue accessible area. This method adequately utilizes the characters of a covering algorithm which have simple, lower(More)
The objective of this study was to investigate cognitive dysfunction in 24–60-year-old neuromyelitis optica (NMO) patients, demographically matched healthy subjects, and MS patients. We conducted a comprehensive literature review of the PubMed, Medline, EMBASE, CNKI, Wan Fang Date, Web of Science, and Cochrane Library databases from inception to May 2016(More)
Determination of the native state of a protein from its amino acid sequence is the goal of protein folding simulations, with potential applications in gene therapy and drug design. To predict a global minimum (GM) structure of a given sequence is a difficult task. A genetic algorithm (GA) is an efficient approach to find lowest-energy conformation for HP(More)
We undertook this project in response to the rapidly increasing number of protein structures with unknown functions in the Protein Data Bank. Here, we combined a genetic algorithm with a support vector machine to predict protein-protein binding sites. In an experiment on a testing dataset, we predicted the binding sites for 66% of our datasets, made up of(More)
With the development of bioinformatics, more and more protein sequence information has become available. Meanwhile, the number of known protein-protein interactions (PPIs) is still very limited. In this article, we propose a new method for predicting interacting protein pairs using a Bayesian method based on a new feature representation. We trained our(More)
The paper presents an approach to optimize the protein 3D HP model conformation with ant colony optimisation (ACO). A rapid coordinate system transfer matrix according to the "right hand" rule we defined is used to reduce the computing time. A new scheme to solve the problem of folding deadlock is suggested. During the update of pheromone, a new update(More)