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C-X-C chemokine receptor 4 (CXCR4) is frequently over-expressed in various types of cancer; many agents against CXCR4 are in clinical development currently despite variable data for the prognostic impact of CXCR4 expression. Here eighty-five studies with a total of 11,032 subjects were included to explore the association between CXCR4 and progression-free(More)
BACKGROUND Glioma is rarely curable, and factors that influence the prognosis of glioma patients are not fully understood. Loss of heterozygosity (LOH) of 1p/19q has long been known to be a typical molecular signature of oligodendroglial neoplasms. However, whether LOH of 1p/19q is associated with survival in gliomas remains controversial. Here our goal was(More)
Human fetal neural stem cells (hNSCs) are used to treat a variety of neurological disorders involving spinal cord injury (SCI). Although their mechanism of action has been attributed to cell substitution, we examined the possibility that NSCs may have neuroprotective activities. The present article studied the action of hNSCs on protecting neurons and(More)
Modern product development becomes increasingly collaborative and parallel, which raises the need for sharing simulation resources in a multi-tenant simulation environment. However, the service requests and scheduling policies of tenants differ since system resources are shared by tenants. In order to deal with this issue, the framework of monitoring,(More)
Schedule and cost factors are largely related to the successful performance of a complex product manufacturing or acquisitions processes. Nonetheless, traditional statistics methods cannot effectively meet the requirement of the complex product management. In this paper, the Weibull distribution with modified least squares estimation (LSE) method is(More)
An idealized model consisting of a thermal conductor and a thermal insulator separated by a thin layer of lubricating fluid is developed to investigate thermoelastic instability with fluid lubrication. The governing equations are solved for the critical speed. A new dimensionless parameter H 0 is defined to predict the critical speed. Furthermore, the(More)
Erythropoietin (EPO) has a neuroprotective effect and can resist aging, which most likely occur through EPO increasing the activity of antioxidant enzymes and scavenging free radicals. In this study, we verified the anti-aging function of EPO and discussed the mechanism occurring through the extracellular signal-regulated kinase (ERK)/NF-E2-related factor 2(More)