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Efficient optical clearance is fundamental for whole brain imaging. In particular, clearance of the brain without membrane damage is required for the imaging of lipophilic tracer-labeled neural tracts. Relying on an ascending gradient of fructose solutions, SeeDB can achieve sufficient transparency of the mouse brain while ensuring that the plasma membrane(More)
BACKGROUND AND OBJECTIVES High energy loss of 1,319 nm laser due to pre-retinal water absorption makes the ocular axial length more critical, while the relative low absorbance of melanin makes retinal pigmented epithelium less contributing, to retinal damage threshold. However, both have never been illustrated experimentally. Here we determined and compared(More)
The corneal damage effects induced by 1319-nm transitional near-infrared laser have been investigated for years. However, the damage threshold dependence on exposure duration has not been revealed. The in vivo corneal damage thresholds (ED50s) were determined in New Zealand rabbits for 1319-nm laser radiation for exposure durations from 75 ms to 10 s. An(More)
BACKGROUND AND OBJECTIVES The purpose of this study was to explore the retinal injury thresholds in rabbits and evaluate the influence of retinal pigmentation on threshold irradiance at laser wavelengths of 532, 578, and 630 nm which might be involved in hypocrellin B (HB) and hematoporphyrin monomethyl ether (HMME) photodynamic therapy (PDT) for choroidal(More)
The ocular damage effects induced by transitional near-infrared (NIR) lasers have been investigated for years. However, no retinal damage thresholds are determined in a wide interval between 0.65 ms and 80 ms, and a definite relationship between corneal damage threshold and spot size cannot be drawn from existing data points. In this paper, the in-vivo(More)
Ting Chen 1,2,*, Xiangmo Zhao 1, Liang Dai 3, Licheng Zhang 1 and Jiarui Wang 1 1 School of Information Engineering, Chang’an University, Xi’an 710064, China; xmzhao@chd.edu.cn (X.Z.); lczhang@chd.edu.cn (L.Z.); wswjr1100@sina.com (J.W.) 2 School of Electrical and Information Engineering, the University of Sydney, Sydney 2006, NSW, Australia 3 School of(More)
The retinal damage effects induced by transitional near-infrared (NIR) lasers have been investigated for years. However, the damage threshold dependence on exposure duration has not been revealed. In this paper, the in-vivo retinal damage ED50 thresholds were determined in chinchilla grey rabbits for 1319 nm laser radiation for exposure durations from 0.1 s(More)
In this paper, a boundary-conformed tool path generation method for either compound or trimmed surfaces are proposed, based on two powerful reparametrization schemes- the discretized harmonic mapping and the convex combination mapping. By globally mapping a 3D surface onto a 2D unit square and then planning an iso-parametric curve in the 2D domain, the(More)
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