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BACKGROUND OX40Ig and CTLA4Ig fusion proteins have been suggested to induce immune tolerance and prevent rejection in allografts. The present study aims to investigate and compare the effects of ex vivo combined OX40Ig and CTLA4Ig lentivirus-mediated gene transfer on the long-term survival of the graft, as well as potential underlying mechanisms. METHODS(More)
BACKGROUND OBJECTIVES Semaphorin 4D (Sema4D) and its receptor, Plexin-B1, are involved in the pathogenesis of squamous cell carcinoma (SCC) by mediating angiogenesis or perineural invasion through the interaction between Sema4D expression on SCC cells and Plexin-B1 expression on endothelial cells or nerves. Plexin-B1 was also recently found to be expressed(More)
Locality Sensitive Hashing (LSH) is widely recognized as one of the most promising approaches to similarity search in high-dimensional spaces. Based on LSH, a considerable number of nearest neighbor search algorithms have been proposed in the past, with some of them having been used in many real-life applications. Apart from their demonstrated superior(More)
Hepatocellular carcinoma (HCC) is one of the most common types of liver cancers with high recurrence rate and mortality rate. Recent studies have indicated that tetramethylpyrazine (TMP), a purified chemical extracted from Ligusticum wallichii Franchat (ChuanXiong), possessed antitumor effects on HCC, but detailed mechanism remains unclear. Our study aims(More)
The utilization bounds for partitioned multiprocessor scheduling are a function of task allocation algorithms and the schedulability conditions selected for uniprocessor scheduling algorithms. In this paper, we use rate-monotonic scheduling on each processor and present the lower and upper limits of the utilization bounds for all reasonable task allocation(More)
To verify the feasibility of real-time task sets on homogeneous multiprocessor systems, Lopez et al. derived the utilization bound based on Best Fit Decreasing allocation algorithm and Rate-Monotonic scheduling, which coincides with the maximum achievable multiprocessor utilization bound, using Liu & Lyland bound as the uniprocessor schedulability(More)
Mast cells are unique immune cells that function as sentinels in host defence reactions, including immediate hypersensitivity responses and allergic responses. The mast cell-specific receptor named MAS-related G protein-coupled receptor X2 (MRGPRX2) triggers mast-cell degranulation, a key process in anaphylactoid reactions. It is widely observed that(More)
During viral infection in vertebrates, cytokines play important roles in the host defense against the virus. However, the function of cytokines in invertebrates has not been well characterized. In this study, shrimp cytokines involved in viral infection were screened using a cytokine antibody microarray. The results showed that three cytokines, the Fas(More)
A moderately halophilic bacteria designed strain NY-011T was isolated from the high salt culture of Dunaliella salina in Chengdu of Sichuan Province, China. The isolate was Gram-negative, nonmotile, rod-shaped and 12.5–21.6 μm in length. Colonies on solid media are circular, wet, smooth and cream. The strain grew optimally at 37 °C, pH 7.0 and in the(More)
It is challenging to develop a robust nanoprobe for real-time operational and accurate detection of heavy metals in single cells. Fe-CN coordination chemistry has been well studied to determine the structural characteristics of hemeproteins by different techniques. However, the frequently used cyanide ligands are inorganic molecules that release cyanide(More)